Gene description for NUDT11
Gene name nudix (nucleoside diphosphate linked moiety X)-type motif 11
Gene symbol NUDT11
Other names/aliases APS1
ASP1
DIPP3b
DIPP3beta
hDIPP3beta
Species Homo sapiens
 Database cross references - NUDT11
ExoCarta ExoCarta_55190
Vesiclepedia VP_55190
Entrez Gene 55190
HGNC 18011
MIM 300528
UniProt Q96G61  
 NUDT11 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NUDT11
Molecular Function
    endopolyphosphatase activity GO:0000298 IBA
    protein binding GO:0005515 IPI
    diphosphoinositol-polyphosphate diphosphatase activity GO:0008486 IBA
    diphosphoinositol-polyphosphate diphosphatase activity GO:0008486 ISS
    bis(5'-adenosyl)-hexaphosphatase activity GO:0034431 IBA
    bis(5'-adenosyl)-pentaphosphatase activity GO:0034432 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    diphosphoinositol polyphosphate metabolic process GO:0071543 IBA
    diadenosine pentaphosphate catabolic process GO:1901907 IBA
    diadenosine hexaphosphate catabolic process GO:1901909 IBA
    adenosine 5'-(hexahydrogen pentaphosphate) catabolic process GO:1901911 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified NUDT11 in sEVs
1
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NUDT11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
2 ANKLE2 23141
Affinity Capture-MS Homo sapiens
3 PCBP1 5093
Affinity Capture-MS Homo sapiens
4 SERBP1 26135
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NUDT11 is involved
PathwayEvidenceSource
Inositol phosphate metabolism TAS Reactome
Metabolism TAS Reactome
Synthesis of pyrophosphates in the cytosol TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here