Gene description for PRX
Gene name periaxin
Gene symbol PRX
Other names/aliases CMT4F
Species Homo sapiens
 Database cross references - PRX
ExoCarta ExoCarta_57716
Entrez Gene 57716
HGNC 13797
MIM 605725
UniProt Q9BXM0  
 PRX identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PRX
Molecular Function
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
Biological Process
    axon ensheathment GO:0008366 NAS
Subcellular Localization
    cellular_component GO:0005575 ND
    plasma membrane GO:0005886 IEA
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified PRX in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PRX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRX 57716
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 DRP2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 DAG1 1605
Affinity Capture-Western Homo sapiens
4 EZR 7430
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PRX is involved
No pathways found

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