Gene description for PRDM13
Gene name PR domain containing 13
Gene symbol PRDM13
Other names/aliases MU-MB-20.220
PFM10
Species Homo sapiens
 Database cross references - PRDM13
ExoCarta ExoCarta_59336
Vesiclepedia VP_59336
Entrez Gene 59336
HGNC 13998
UniProt Q9H4Q3  
 PRDM13 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for PRDM13
Molecular Function
    DNA binding GO:0003677 IEA
    chromatin binding GO:0003682 IEA
    DNA-binding transcription factor activity GO:0003700 IEA
    histone methyltransferase activity GO:0042054 ISS
    metal ion binding GO:0046872 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    chromatin remodeling GO:0006338 IEA
    regulation of gene expression GO:0010468 IBA
    hypothalamus cell differentiation GO:0021979 IEA
    methylation GO:0032259 IEA
    GABAergic neuron differentiation GO:0097154 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
 Experiment description of studies that identified PRDM13 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PRDM13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPM1B 5495
Affinity Capture-MS Homo sapiens
2 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
3 HIST1H4I 8294
Affinity Capture-MS Homo sapiens
4 HIST1H2BK 85236
Affinity Capture-MS Homo sapiens
5 TUBA1B 10376
Affinity Capture-MS Homo sapiens
6 EIF4B 1975
Affinity Capture-MS Homo sapiens
7 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
8 KDM5B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PRDM13 is involved
No pathways found





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