Gene description for LGR6
Gene name leucine-rich repeat containing G protein-coupled receptor 6
Gene symbol LGR6
Other names/aliases GPCR
VTS20631
Species Homo sapiens
 Database cross references - LGR6
ExoCarta ExoCarta_59352
Vesiclepedia VP_59352
Entrez Gene 59352
HGNC 19719
MIM 606653
UniProt Q9HBX8  
 LGR6 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for LGR6
Molecular Function
    transmembrane signaling receptor activity GO:0004888 ISS
    G protein-coupled receptor activity GO:0004930 ISS
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IBA
    protein-hormone receptor activity GO:0016500 IEA
    Roundabout binding GO:0048495 IBA
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    axon guidance GO:0007411 IBA
    cell population proliferation GO:0008283 IEA
    Wnt signaling pathway GO:0016055 IEA
    positive regulation of Wnt signaling pathway GO:0030177 IDA
    positive regulation of cell migration GO:0030335 IDA
    negative chemotaxis GO:0050919 IBA
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISS
    bone regeneration GO:1990523 IEA
Subcellular Localization
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    vesicle GO:0031982 IDA
    trans-Golgi network membrane GO:0032588 ISS
 Experiment description of studies that identified LGR6 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for LGR6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LNX1  
Two-hybrid Homo sapiens
2 TP53 7157
Negative Genetic Homo sapiens
3 BTF3 689
Affinity Capture-MS Homo sapiens
4 EP300 2033
Affinity Capture-MS Homo sapiens
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