Gene description for LGR6
Gene name leucine-rich repeat containing G protein-coupled receptor 6
Gene symbol LGR6
Other names/aliases GPCR
VTS20631
Species Homo sapiens
 Database cross references - LGR6
ExoCarta ExoCarta_59352
Entrez Gene 59352
HGNC 19719
MIM 606653
UniProt Q9HBX8  
 LGR6 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for LGR6
Molecular Function
    G-protein coupled receptor activity GO:0004930 ISS
    protein binding GO:0005515 IPI
    transmembrane signaling receptor activity GO:0004888 ISS
Biological Process
    Wnt signaling pathway GO:0016055 IEA
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISS
    positive regulation of cell migration GO:0030335 IDA
    positive regulation of Wnt signaling pathway GO:0030177 IDA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 ISS
    trans-Golgi network membrane GO:0032588 ISS
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    vesicle GO:0031982 IDA
 Experiment description of studies that identified LGR6 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for LGR6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LGR6 is involved
PathwayEvidenceSource
regulation of FZD by ubiquitination TAS Reactome





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