Gene description for DPEP3
Gene name dipeptidase 3
Gene symbol DPEP3
Other names/aliases MBD3
Species Homo sapiens
 Database cross references - DPEP3
ExoCarta ExoCarta_64180
Entrez Gene 64180
HGNC 23029
MIM 609926
UniProt Q9H4B8  
 DPEP3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DPEP3
Molecular Function
    dipeptidyl-peptidase activity GO:0008239 IEA
    metal ion binding GO:0046872 IEA
    dipeptidase activity GO:0016805 IEA
    metalloexopeptidase activity GO:0008235 IEA
Biological Process
    proteolysis GO:0006508 IEA
    male meiosis GO:0007140 ISS
Subcellular Localization
    anchored component of membrane GO:0031225 IEA
 Experiment description of studies that identified DPEP3 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DPEP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DPEP3 is involved
PathwayEvidenceSource
Aflatoxin activation and detoxification TAS Reactome
Synthesis of Leukotrienes (LT) and Eoxins (EX) TAS Reactome





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