Gene description for DPEP3
Gene name dipeptidase 3
Gene symbol DPEP3
Other names/aliases MBD3
Species Homo sapiens
 Database cross references - DPEP3
ExoCarta ExoCarta_64180
Vesiclepedia VP_64180
Entrez Gene 64180
HGNC 23029
MIM 609926
UniProt Q9H4B8  
 DPEP3 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DPEP3
Molecular Function
    dipeptidase activity GO:0016805 IDA
    dipeptidase activity GO:0016805 ISS
Biological Process
    proteolysis GO:0006508 IEA
Subcellular Localization
    acrosomal vesicle GO:0001669 ISS
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 ISS
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified DPEP3 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DPEP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DPEP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 EGFR 1956
Affinity Capture-MS Homo sapiens
4 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CHD4 1108
Affinity Capture-MS Homo sapiens
6 LINC00839  
Protein-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which DPEP3 is involved
No pathways found





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