Gene description for WNT7B
Gene name wingless-type MMTV integration site family, member 7B
Gene symbol WNT7B
Other names/aliases -
Species Homo sapiens
 Database cross references - WNT7B
ExoCarta ExoCarta_7477
Vesiclepedia VP_7477
Entrez Gene 7477
HGNC 12787
MIM 601967
UniProt P56706  
 WNT7B identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for WNT7B
Molecular Function
    frizzled binding GO:0005109 IBA
    cytokine activity GO:0005125 IBA
    protein binding GO:0005515 IPI
    receptor ligand activity GO:0048018 IDA
Biological Process
    in utero embryonic development GO:0001701 ISS
    metanephros morphogenesis GO:0003338 ISS
    Wnt signaling pathway GO:0016055 ISS
    establishment or maintenance of polarity of embryonic epithelium GO:0016332 ISS
    forebrain regionalization GO:0021871 IEP
    central nervous system vasculogenesis GO:0022009 ISS
    neuron differentiation GO:0030182 IBA
    neuron differentiation GO:0030182 IEP
    lung development GO:0030324 ISS
    intracellular oxygen homeostasis GO:0032364 ISS
    regulation of cell projection size GO:0032536 IEA
    chemoattraction of dopaminergic neuron axon GO:0036516 ISS
    homeostatic process GO:0042592 ISS
    cell fate commitment GO:0045165 IBA
    positive regulation of osteoblast differentiation GO:0045669 ISS
    positive regulation of JNK cascade GO:0046330 IBA
    fibroblast proliferation GO:0048144 IEP
    embryonic organ development GO:0048568 ISS
    synapse organization GO:0050808 ISS
    response to glucocorticoid GO:0051384 IEA
    canonical Wnt signaling pathway GO:0060070 IBA
    canonical Wnt signaling pathway GO:0060070 IDA
    canonical Wnt signaling pathway GO:0060070 ISS
    Wnt signaling pathway, planar cell polarity pathway GO:0060071 ISS
    lung morphogenesis GO:0060425 ISS
    lung epithelium development GO:0060428 ISS
    lobar bronchus development GO:0060482 ISS
    trachea cartilage morphogenesis GO:0060535 ISS
    developmental growth involved in morphogenesis GO:0060560 ISS
    embryonic placenta morphogenesis GO:0060669 ISS
    chorio-allantoic fusion GO:0060710 ISS
    mammary gland epithelium development GO:0061180 IEP
    lens fiber cell development GO:0070307 ISS
    cellular response to retinoic acid GO:0071300 IEP
    renal inner medulla development GO:0072053 ISS
    renal outer medulla development GO:0072054 ISS
    outer medullary collecting duct development GO:0072060 ISS
    inner medullary collecting duct development GO:0072061 ISS
    stem cell proliferation GO:0072089 IEP
    metanephric collecting duct development GO:0072205 ISS
    metanephric epithelium development GO:0072207 ISS
    metanephric loop of Henle development GO:0072236 ISS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    endoplasmic reticulum lumen GO:0005788 TAS
    Golgi lumen GO:0005796 TAS
    plasma membrane GO:0005886 TAS
    endocytic vesicle membrane GO:0030666 TAS
    extracellular exosome GO:0070062 TAS
 Experiment description of studies that identified WNT7B in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for WNT7B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TCEB1 6921
Two-hybrid Homo sapiens
2 WNT7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CASK 8573
Two-hybrid Homo sapiens
4 CUL3 8452
Two-hybrid Homo sapiens
5 WNT4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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