Gene description for Pacsin3
Gene name protein kinase C and casein kinase substrate in neurons 3
Gene symbol Pacsin3
Other names/aliases 4921507A02Rik
6330413E15Rik
AW413130
Species Mus musculus
 Database cross references - Pacsin3
ExoCarta ExoCarta_80708
Entrez Gene 80708
UniProt Q99JB8  
 Pacsin3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Pacsin3
Molecular Function
    lipid binding GO:0008289 ISO
    calcium channel inhibitor activity GO:0019855 IMP
    phospholipid binding GO:0005543 IBA
    protein binding GO:0005515 IPI
    cytoskeletal protein binding GO:0008092 IDA
Biological Process
    endocytosis GO:0006897 IEA
    cytoskeleton organization GO:0007010 IBA
    negative regulation of calcium ion transport GO:0051926 IMP
    negative regulation of endocytosis GO:0045806 IMP
    membrane tubulation GO:0097320 ISO
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 ISO
Subcellular Localization
    membrane GO:0016020 IBA
    membrane-bounded vesicle GO:0031988 IBA
    trans-Golgi network GO:0005802 IDA
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 ISO
    endosome GO:0005768 IBA
    nucleoplasm GO:0005654 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Pacsin3 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pacsin3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pacsin3 is involved
No pathways found





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