Gene description for Synj1
Gene name synaptojanin 1
Gene symbol Synj1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Synj1
ExoCarta ExoCarta_85238
Entrez Gene 85238
UniProt Q62910  
 Synj1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Synj1
Molecular Function
    RNA binding GO:0003723 IEA
    protein C-terminus binding GO:0008022 IPI
    SH3 domain binding GO:0017124 IPI
    phosphatidylinositol phosphate 5-phosphatase activity GO:0034595 ISO
    nucleotide binding GO:0000166 IEA
    nucleic acid binding GO:0003676 IEA
    phosphoric ester hydrolase activity GO:0042578 IEA
    protein complex binding GO:0032403 IDA
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 ISS
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of gliogenesis GO:0014015 IMP
    learning GO:0007612 ISO
    positive regulation of receptor-mediated endocytosis GO:0048260 IMP
    response to cytokine GO:0034097 IMP
    brain development GO:0007420 IEP
    neurotransmitter transport GO:0006836 ISS
    synaptic vesicle priming GO:0016082 ISS
    phosphatidylinositol metabolic process GO:0046488 ISS
    phosphatidylinositol dephosphorylation GO:0046856 ISS
    synaptic vesicle uncoating GO:0016191 ISS
    response to retinoic acid GO:0032526 IMP
    synaptic vesicle endocytosis GO:0048488 ISS
    synaptic vesicle transport GO:0048489 ISS
    inositol phosphate dephosphorylation GO:0046855 ISS
Subcellular Localization
    protein complex GO:0043234 IDA
    cytoplasm GO:0005737 IDA
    neuron projection GO:0043005 IDA
    membrane coat GO:0030117 ISS
    cell GO:0005623 ISO
 Experiment description of studies that identified Synj1 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Synj1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Synj1 is involved
No pathways found





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