Gene description for OPN4
Gene name opsin 4
Gene symbol OPN4
Other names/aliases MOP
Species Homo sapiens
 Database cross references - OPN4
ExoCarta ExoCarta_94233
Vesiclepedia VP_94233
Entrez Gene 94233
HGNC 14449
MIM 606665
UniProt Q9UHM6  
 OPN4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for OPN4
Molecular Function
    11-cis retinal binding GO:0005502 IDA
    protein binding GO:0005515 IPI
    G protein-coupled photoreceptor activity GO:0008020 IBA
    G protein-coupled photoreceptor activity GO:0008020 IDA
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    visual perception GO:0007601 IEA
    phototransduction GO:0007602 IBA
    phototransduction GO:0007602 IDA
    optokinetic behavior GO:0007634 ISS
    detection of visible light GO:0009584 IEA
    regulation of circadian rhythm GO:0042752 ISS
    thermotaxis GO:0043052 IEA
    rhythmic process GO:0048511 IEA
    detection of temperature stimulus involved in thermoception GO:0050960 IEA
    retina development in camera-type eye GO:0060041 IEA
    cellular response to light stimulus GO:0071482 IBA
    hyaloid vascular plexus regression GO:1990384 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 TAS
    axon GO:0030424 IEA
    dendrite GO:0030425 IEA
    perikaryon GO:0043204 IEA
    photoreceptor disc membrane GO:0097381 TAS
    sperm head plasma membrane GO:1990913 IEA
 Experiment description of studies that identified OPN4 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for OPN4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDFIP1 80762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 UBQLN2 29978
Two-hybrid Homo sapiens
3 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 STX10 8677
Affinity Capture-MS Homo sapiens
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