Gene description for OPN4
Gene name opsin 4
Gene symbol OPN4
Other names/aliases MOP
Species Homo sapiens
 Database cross references - OPN4
ExoCarta ExoCarta_94233
Entrez Gene 94233
HGNC 14449
MIM 606665
UniProt Q9UHM6  
 OPN4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for OPN4
Molecular Function
    11-cis retinal binding GO:0005502 IDA
    G-protein coupled photoreceptor activity GO:0008020 IDA
Biological Process
    visual perception GO:0007601 IEA
    phototransduction GO:0007602 IDA
    protein-chromophore linkage GO:0018298 IEA
    rhodopsin mediated signaling pathway GO:0016056 IEA
    regulation of circadian rhythm GO:0042752 ISS
    rhythmic process GO:0048511 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 TAS
 Experiment description of studies that identified OPN4 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for OPN4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which OPN4 is involved
PathwayEvidenceSource
G alpha (q) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
Opsins TAS Reactome





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