Gene description for Hnrnpc
Gene name heterogeneous nuclear ribonucleoprotein C
Gene symbol Hnrnpc
Other names/aliases AL022939
D14Wsu171e
Hnrpc
Hnrpc1
Hnrpc2
hnRNPC1
hnRNPC2
hnrnp-C
Species Mus musculus
 Database cross references - Hnrnpc
ExoCarta ExoCarta_15381
Vesiclepedia VP_15381
Entrez Gene 15381
UniProt Q9Z204  
 Hnrnpc identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hnrnpc
Molecular Function
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 ISO
    mRNA binding GO:0003729 IDA
    mRNA binding GO:0003729 ISO
    mRNA 3'-UTR binding GO:0003730 ISO
    enzyme inhibitor activity GO:0004857 ISO
    poly(U) RNA binding GO:0008266 ISO
    protein domain specific binding GO:0019904 ISO
    identical protein binding GO:0042802 ISO
    ribonucleoprotein complex binding GO:0043021 ISO
    telomerase RNA binding GO:0070034 ISO
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISO
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISS
    deaminase binding GO:1990827 ISO
Biological Process
    mRNA splicing, via spliceosome GO:0000398 ISO
    mRNA splicing, via spliceosome GO:0000398 ISS
    negative regulation of telomere maintenance via telomerase GO:0032211 ISO
    3'-UTR-mediated mRNA stabilization GO:0070935 ISO
    negative regulation of mRNA modification GO:0090367 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    spliceosomal complex GO:0005681 ISO
    spliceosomal complex GO:0005681 ISS
    telomerase holoenzyme complex GO:0005697 ISO
    cytosol GO:0005829 ISO
    actin cytoskeleton GO:0015629 ISO
    actin cytoskeleton GO:0015629 ISS
    protein-containing complex GO:0032991 ISO
    protein-containing complex GO:0032991 ISS
    pronucleus GO:0045120 IDA
    catalytic step 2 spliceosome GO:0071013 ISO
    nucleoplasmic periphery of the nuclear pore complex GO:1990826 ISO
 Experiment description of studies that identified Hnrnpc in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hnrnpc
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sf3a3 75062
Co-fractionation Mus musculus
2 Ddx5 13207
Co-fractionation Mus musculus
3 Cdc5l 71702
Co-fractionation Mus musculus
4 Syncrip 56403
Co-fractionation Mus musculus
5 Ube2i  
Two-hybrid Mus musculus
6 Hnrnpu 51810
Co-fractionation Mus musculus
7 Atxn1  
Affinity Capture-MS Mus musculus
8 Kctd13  
Affinity Capture-MS Mus musculus
9 Tfe3  
Affinity Capture-MS Mus musculus
10 Snrnp200 320632
Co-fractionation Mus musculus
11 HNRNPCL1 343069
Two-hybrid Homo sapiens
12 Mecp2  
Affinity Capture-MS Mus musculus
13 Kpna3 16648
Co-fractionation Mus musculus
14 Sf3b3 101943
Co-fractionation Mus musculus
15 Hnrnph1 59013
Co-fractionation Mus musculus
16 Tmem173  
Proximity Label-MS Mus musculus
17 Ctnnbl1  
Co-fractionation Mus musculus
18 Srrm2  
Co-fractionation Mus musculus
19 Hnrnpa3 229279
Co-fractionation Mus musculus
20 Ppie  
Co-fractionation Mus musculus
21 Plrg1  
Co-fractionation Mus musculus
22 Snw1  
Co-fractionation Mus musculus
23 Fancd2  
Affinity Capture-MS Mus musculus
24 Hnrnpf 98758
Co-fractionation Mus musculus
25 Eed  
Affinity Capture-MS Mus musculus
26 Cwc27  
Co-fractionation Mus musculus
27 U2af2 22185
Co-fractionation Mus musculus
28 Sf1 22668
Co-fractionation Mus musculus
29 Skiv2l2  
Co-fractionation Mus musculus
30 Eif4a3 192170
Co-fractionation Mus musculus
31 Eftud2 20624
Co-fractionation Mus musculus
32 Hnrnpa2b1 53379
Co-fractionation Mus musculus
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