Gene description for DDIT3
Gene name	DNA-damage-inducible transcript 3
Gene symbol	DDIT3
Other names/aliases	CEBPZ CHOP CHOP-10 CHOP10 GADD153
Species	Homo sapiens
Database cross references - DDIT3
ExoCarta	ExoCarta_1649
Vesiclepedia	VP_1649
Entrez Gene	1649
HGNC	2726
MIM	126337
UniProt	P35638
DDIT3 identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for DDIT3

Molecular Function     transcription cis-regulatory region binding GO:0000976 IC     transcription cis-regulatory region binding GO:0000976 IDA     transcription cis-regulatory region binding GO:0000976 ISS     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA     DNA binding GO:0003677 IDA     DNA-binding transcription factor activity GO:0003700 IDA     DNA-binding transcription factor activity GO:0003700 IGI     DNA-binding transcription factor activity GO:0003700 ISS     transcription corepressor activity GO:0003714 IDA     transcription corepressor activity GO:0003714 IGI     protein binding GO:0005515 IPI     cAMP response element binding protein binding GO:0008140 IPI     cAMP response element binding protein binding GO:0008140 ISS     identical protein binding GO:0042802 IPI     protein homodimerization activity GO:0042803 IDA     leucine zipper domain binding GO:0043522 IDA     protein heterodimerization activity GO:0046982 IBA     protein heterodimerization activity GO:0046982 IPI     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     transcription regulator inhibitor activity GO:0140416 ISS     transcription regulator activator activity GO:0140537 ISS Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IBA     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IGI     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     blood vessel maturation GO:0001955 IEA     regulation of DNA-templated transcription GO:0006355 IMP     regulation of transcription by RNA polymerase II GO:0006357 IDA     regulation of transcription by RNA polymerase II GO:0006357 IDA     regulation of transcription by RNA polymerase II GO:0006357 NAS     DNA damage response GO:0006974 TAS     ER overload response GO:0006983 IBA     response to unfolded protein GO:0006986 IDA     sensory perception of sound GO:0007605 IEA     response to wounding GO:0009611 IEA     anterior/posterior axis specification GO:0009948 ISS     gene expression GO:0010467 IEA     regulation of autophagy GO:0010506 ISS     Wnt signaling pathway GO:0016055 IEA     endoplasmic reticulum unfolded protein response GO:0030968 ISS     negative regulation of type II interferon production GO:0032689 IMP     negative regulation of interleukin-17 production GO:0032700 IMP     negative regulation of interleukin-4 production GO:0032713 IMP     positive regulation of interleukin-8 production GO:0032757 IMP     response to endoplasmic reticulum stress GO:0034976 IDA     response to endoplasmic reticulum stress GO:0034976 IGI     response to platelet-derived growth factor GO:0036119 IEA     PERK-mediated unfolded protein response GO:0036499 TAS     ATF6-mediated unfolded protein response GO:0036500 TAS     response to starvation GO:0042594 IEA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     positive regulation of neuron apoptotic process GO:0043525 ISS     cell redox homeostasis GO:0045454 IDA     negative regulation of fat cell differentiation GO:0045599 IEA     negative regulation of myoblast differentiation GO:0045662 IEA     negative regulation of DNA-templated transcription GO:0045892 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IGI     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     positive regulation of DNA-binding transcription factor activity GO:0051091 IMP     release of sequestered calcium ion into cytosol GO:0051209 IEA     regulation of cell cycle GO:0051726 IEA     negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IMP     artery development GO:0060840 IEA     intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IBA     intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IDA     intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IMP     intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 TAS     establishment of protein localization to mitochondrion GO:0072655 IEA     negative regulation of canonical Wnt signaling pathway GO:0090090 ISS     negative regulation of cold-induced thermogenesis GO:0120163 ISS     integrated stress response signaling GO:0140467 IDA     integrated stress response signaling GO:0140467 NAS     HRI-mediated signaling GO:0140468 IDA     vascular associated smooth muscle cell migration GO:1904738 IEA     intrinsic apoptotic signaling pathway in response to nitrosative stress GO:1990442 IEA     vascular associated smooth muscle cell proliferation GO:1990874 IEA     negative regulation of determination of dorsal identity GO:2000016 IDA     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IMP Subcellular Localization     chromatin GO:0000785 ISA     nucleus GO:0005634 IDA     nucleus GO:0005634 NAS     transcription regulator complex GO:0005667 NAS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     late endosome GO:0005770 IEA     cytosol GO:0005829 TAS     protein-DNA complex GO:0032993 IDA     CHOP-C/EBP complex GO:0036488 IBA     CHOP-C/EBP complex GO:0036488 IPI     CHOP-C/EBP complex GO:0036488 ISS     CHOP-C/EBP complex GO:0036488 TAS     RNA polymerase II transcription regulator complex GO:0090575 IPI     CHOP-ATF4 complex GO:1990617 IBA     CHOP-ATF4 complex GO:1990617 IDA     CHOP-ATF4 complex GO:1990617 IPI     CHOP-ATF3 complex GO:1990622 IBA     CHOP-ATF3 complex GO:1990622 IDA