Gene description for PRKCZ
Gene name	protein kinase C, zeta
Gene symbol	PRKCZ
Other names/aliases	PKC-ZETA PKC2
Species	Homo sapiens
Database cross references - PRKCZ
ExoCarta	ExoCarta_5590
Vesiclepedia	VP_5590
Entrez Gene	5590
HGNC	9412
MIM	176982
UniProt	Q05513
PRKCZ identified in sEVs derived from the following tissue/cell type
Urine	19056867

Gene ontology annotations for PRKCZ

Molecular Function     protein kinase activity GO:0004672 IDA     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     diacylglycerol-dependent serine/threonine kinase activity GO:0004697 EXP     diacylglycerol-dependent serine/threonine kinase activity GO:0004697 TAS     calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0004698 IEA     diacylglycerol-dependent, calcium-independent serine/threonine kinase activity GO:0004699 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     potassium channel regulator activity GO:0015459 IEA     protein kinase binding GO:0019901 IEA     phospholipase binding GO:0043274 IEA     insulin receptor substrate binding GO:0043560 IC     protein-containing complex binding GO:0044877 IEA     metal ion binding GO:0046872 IEA     14-3-3 protein binding GO:0071889 IEA     protein serine kinase activity GO:0106310 IEA Biological Process     microtubule cytoskeleton organization GO:0000226 IEA     positive regulation of cell-matrix adhesion GO:0001954 IEA     protein phosphorylation GO:0006468 IDA     inflammatory response GO:0006954 IEA     signal transduction GO:0007165 TAS     cell surface receptor signaling pathway GO:0007166 IEA     long-term memory GO:0007616 IEA     positive regulation of cell population proliferation GO:0008284 IEA     cell migration GO:0016477 IEA     peptidyl-serine phosphorylation GO:0018105 IDA     establishment of cell polarity GO:0030010 IBA     establishment of cell polarity GO:0030010 ISS     negative regulation of protein-containing complex assembly GO:0031333 IMP     positive regulation of interleukin-10 production GO:0032733 ISS     positive regulation of interleukin-13 production GO:0032736 ISS     positive regulation of interleukin-4 production GO:0032753 ISS     positive regulation of interleukin-5 production GO:0032754 ISS     cellular response to insulin stimulus GO:0032869 IBA     intracellular signal transduction GO:0035556 IBA     negative regulation of apoptotic process GO:0043066 IEA     establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 ISS     positive regulation of T-helper 2 cell differentiation GO:0045630 ISS     negative regulation of insulin receptor signaling pathway GO:0046627 IMP     positive regulation of insulin receptor signaling pathway GO:0046628 ISS     vesicle transport along microtubule GO:0047496 IEA     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IMP     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS     positive regulation of protein transport GO:0051222 IEA     membrane depolarization GO:0051899 IEA     membrane hyperpolarization GO:0060081 IEA     long-term synaptic potentiation GO:0060291 ISS     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     protein kinase C signaling GO:0070528 IEA     protein localization to plasma membrane GO:0072659 IBA     regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IEA     neuron projection extension GO:1990138 IEA     positive regulation of excitatory postsynaptic potential GO:2000463 ISS     positive regulation of T-helper 2 cell cytokine production GO:2000553 ISS Subcellular Localization     stress fiber GO:0001725 IEA     nuclear envelope GO:0005635 IEA     cytoplasm GO:0005737 TAS     endosome GO:0005768 IEA     microtubule organizing center GO:0005815 IEA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IDA     cell-cell junction GO:0005911 IDA     bicellular tight junction GO:0005923 IEA     postsynaptic density GO:0014069 IEA     membrane GO:0016020 TAS     apical plasma membrane GO:0016324 IEA     nuclear matrix GO:0016363 IEA     cell junction GO:0030054 TAS     cell leading edge GO:0031252 IEA     vesicle GO:0031982 IDA     myelin sheath abaxonal region GO:0035748 IEA     axon hillock GO:0043203 IEA     apical cortex GO:0045179 IEA     perinuclear region of cytoplasm GO:0048471 IEA     extracellular exosome GO:0070062 HDA     tight junction GO:0070160 NAS     Schaffer collateral - CA1 synapse GO:0098685 IEA     glutamatergic synapse GO:0098978 IEA     PAR polarity complex GO:0120157 ISS