Gene description for PKN2
Gene name protein kinase N2
Gene symbol PKN2
Other names/aliases PAK2
PRK2
PRKCL2
PRO2042
Pak-2
STK7
Species Homo sapiens
 Database cross references - PKN2
ExoCarta ExoCarta_5586
Vesiclepedia VP_5586
Entrez Gene 5586
HGNC 9406
MIM 602549
UniProt Q16513  
 PKN2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Malignant pleural effusions 14975938    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PKN2
Molecular Function
    RNA binding GO:0003723 HDA
    protein kinase activity GO:0004672 TAS
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0004698 IEA
    diacylglycerol-dependent, calcium-independent serine/threonine kinase activity GO:0004699 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    kinase activity GO:0016301 IDA
    small GTPase binding GO:0031267 IEA
    histone deacetylase binding GO:0042826 IDA
    cadherin binding GO:0045296 HDA
    RNA polymerase binding GO:0070063 IPI
    protein serine kinase activity GO:0106310 IEA
Biological Process
    protein phosphorylation GO:0006468 IDA
    apoptotic process GO:0006915 IEA
    cell adhesion GO:0007155 IEA
    signal transduction GO:0007165 TAS
    epithelial cell migration GO:0010631 IDA
    cell projection organization GO:0030030 IEA
    positive regulation of cytokinesis GO:0032467 IMP
    intracellular signal transduction GO:0035556 IBA
    apical junction assembly GO:0043297 IMP
    positive regulation of viral genome replication GO:0045070 IMP
    positive regulation of mitotic cell cycle GO:0045931 IMP
    cell division GO:0051301 IEA
    regulation of cell motility GO:2000145 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    nuclear body GO:0016604 IDA
    lamellipodium GO:0030027 IDA
    midbody GO:0030496 IDA
    cleavage furrow GO:0032154 IDA
    protein-containing complex GO:0032991 IDA
    apical junction complex GO:0043296 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified PKN2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 52
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors "Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN"
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Lung cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
16
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
17
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PKN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAMKV 79012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 TRMT1L 81627
Affinity Capture-MS Homo sapiens
4 NPRL2  
Affinity Capture-MS Homo sapiens
5 PPIAL4G  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 DNAJC8 22826
Affinity Capture-MS Homo sapiens
7 ZNF747  
Affinity Capture-MS Homo sapiens
8 PARD3 56288
Proximity Label-MS Homo sapiens
9 TMUB1  
Affinity Capture-MS Homo sapiens
10 TMSB10 9168
Cross-Linking-MS (XL-MS) Homo sapiens
11 RPL35A 6165
Affinity Capture-MS Homo sapiens
12 LSM4 25804
Co-fractionation Homo sapiens
13 KARS 3735
Affinity Capture-MS Homo sapiens
14 MILR1  
Affinity Capture-MS Homo sapiens
15 TGM2 7052
Affinity Capture-MS Homo sapiens
16 CAPZB 832
Affinity Capture-MS Homo sapiens
17 DARS 1615
Affinity Capture-MS Homo sapiens
18 VARS 7407
Affinity Capture-MS Homo sapiens
19 WDR20 91833
Affinity Capture-MS Homo sapiens
20 ZNF524  
Affinity Capture-MS Homo sapiens
21 WDR74 54663
Affinity Capture-MS Homo sapiens
22 Map3k2  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Biochemical Activity Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
23 FAM193B 54540
Two-hybrid Homo sapiens
24 ATP2A2 488
Affinity Capture-MS Homo sapiens
25 RHOA 387
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Far Western Homo sapiens
26 PLCG1 5335
Reconstituted Complex Homo sapiens
27 KTN1 3895
Affinity Capture-MS Homo sapiens
28 CES2 8824
Affinity Capture-MS Homo sapiens
29 TULP3 7289
Affinity Capture-MS Homo sapiens
30 EEF1G 1937
Affinity Capture-MS Homo sapiens
31 PKN2 5586
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
32 NCK1 4690
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
33 NEDD4 4734
Reconstituted Complex Homo sapiens
34 EEF1A1 1915
Two-hybrid Homo sapiens
35 KIF14 9928
Affinity Capture-MS Homo sapiens
36 AKT1 207
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
37 LSM2 57819
Co-fractionation Homo sapiens
38 C15orf59  
Affinity Capture-MS Homo sapiens
39 UNK  
Affinity Capture-RNA Homo sapiens
40 PPM1B 5495
Co-fractionation Homo sapiens
41 PDK1 5163
Affinity Capture-Western Homo sapiens
42 USP11 8237
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RUFY1 80230
Affinity Capture-MS Homo sapiens
44 PARK2  
Affinity Capture-MS Homo sapiens
45 TRAM1 23471
Affinity Capture-MS Homo sapiens
46 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
47 MARS 4141
Affinity Capture-MS Homo sapiens
48 MCAM 4162
Proximity Label-MS Homo sapiens
49 RPE  
Co-fractionation Homo sapiens
50 DNAJC5 80331
Proximity Label-MS Homo sapiens
51 CCNB1 891
Affinity Capture-MS Homo sapiens
52 KDM4B  
Affinity Capture-MS Homo sapiens
53 CDH1 999
Proximity Label-MS Homo sapiens
54 BTF3 689
Affinity Capture-MS Homo sapiens
55 VCP 7415
Affinity Capture-MS Homo sapiens
56 PNMA2  
Affinity Capture-MS Homo sapiens
57 THBS3 7059
Affinity Capture-MS Homo sapiens
58 EEF1E1 9521
Affinity Capture-MS Homo sapiens
59 PKN1 5585
Affinity Capture-MS Homo sapiens
60 CTNNA3  
Affinity Capture-MS Homo sapiens
61 IARS 3376
Affinity Capture-MS Homo sapiens
62 DEF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 HDAC5 10014
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
64 CEBPA  
Affinity Capture-MS Homo sapiens
65 ZNF8  
Affinity Capture-MS Homo sapiens
66 UBXN6 80700
Affinity Capture-MS Homo sapiens
67 FRMPD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 ACBD3 64746
Co-fractionation Homo sapiens
69 RPA3 6119
Proximity Label-MS Homo sapiens
70 CETN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 EIF3G 8666
Two-hybrid Homo sapiens
72 ZBTB2 57621
Affinity Capture-MS Homo sapiens
73 SGPL1 8879
Affinity Capture-MS Homo sapiens
74 MOB1B 92597
Affinity Capture-MS Homo sapiens
75 VAPB 9217
Affinity Capture-MS Homo sapiens
76 PTEN 5728
Affinity Capture-MS Homo sapiens
77 CCT6A 908
Co-fractionation Homo sapiens
78 CHGB 1114
Two-hybrid Homo sapiens
79 ATP5F1 515
Affinity Capture-MS Homo sapiens
80 GOPC 57120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 CYP1A1  
Affinity Capture-MS Homo sapiens
82 EPRS 2058
Affinity Capture-MS Homo sapiens
83 PDPK1 5170
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
84 PDCD11 22984
Affinity Capture-MS Homo sapiens
85 LARS 51520
Affinity Capture-MS Homo sapiens
86 FKBP5 2289
Affinity Capture-MS Homo sapiens
87 MBOAT7 79143
Affinity Capture-MS Homo sapiens
88 SOAT1 6646
Affinity Capture-MS Homo sapiens
89 HECW2  
Affinity Capture-MS Homo sapiens
90 LSM3 27258
Co-fractionation Homo sapiens
91 EGFR 1956
Negative Genetic Homo sapiens
92 LGALS7B 653499
Affinity Capture-MS Homo sapiens
93 MYO9B 4650
Two-hybrid Homo sapiens
94 JUNB  
Affinity Capture-MS Homo sapiens
95 RHOB 388
Proximity Label-MS Homo sapiens
96 LGALS7 3963
Affinity Capture-MS Homo sapiens
97 CETN2 1069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 AHSA1 10598
Affinity Capture-Western Homo sapiens
99 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
100 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PARP1 142
Proximity Label-MS Homo sapiens
102 TGFBR2 7048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 ERLIN1 10613
Affinity Capture-MS Homo sapiens
104 TBC1D9  
Affinity Capture-MS Homo sapiens
105 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
107 DFFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
109 KCNE3  
Affinity Capture-MS Homo sapiens
110 NCK2 8440
Affinity Capture-Western Homo sapiens
111 ANAPC2 29882
Proximity Label-MS Homo sapiens
112 PHKA2 5256
Affinity Capture-MS Homo sapiens
113 RABL3 285282
Affinity Capture-MS Homo sapiens
114 SKAP1 8631
Affinity Capture-MS Homo sapiens
115 LSM7  
Co-fractionation Homo sapiens
116 PSMA5 5686
Affinity Capture-MS Homo sapiens
117 EEF1D 1936
Affinity Capture-MS Homo sapiens
118 LSM6 11157
Co-fractionation Homo sapiens
119 SNW1 22938
Affinity Capture-MS Homo sapiens
120 KRAS 3845
Proximity Label-MS Homo sapiens
121 RARS 5917
Affinity Capture-MS Homo sapiens
122 CCDC136  
Two-hybrid Homo sapiens
123 CKAP4 10970
Affinity Capture-MS Homo sapiens
124 PTPN13 5783
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
125 EP300 2033
Affinity Capture-MS Homo sapiens
126 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here