Gene description for SLC43A2
Gene name solute carrier family 43 (amino acid system L transporter), member 2
Gene symbol SLC43A2
Other names/aliases LAT4
Species Homo sapiens
 Database cross references - SLC43A2
ExoCarta ExoCarta_124935
Vesiclepedia VP_124935
Entrez Gene 124935
HGNC 23087
MIM 610791
UniProt Q8N370  
 SLC43A2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC43A2
Molecular Function
    protein binding GO:0005515 IPI
    amino acid transmembrane transporter activity GO:0015171 TAS
    neutral L-amino acid transmembrane transporter activity GO:0015175 IBA
    L-amino acid transmembrane transporter activity GO:0015179 IBA
    L-isoleucine transmembrane transporter activity GO:0015188 IDA
    L-leucine transmembrane transporter activity GO:0015190 IDA
    L-methionine transmembrane transporter activity GO:0015191 IDA
    L-phenylalanine transmembrane transporter activity GO:0015192 IDA
    L-phenylalanine transmembrane transporter activity GO:0015192 ISS
Biological Process
    amino acid transport GO:0006865 TAS
    neutral amino acid transport GO:0015804 IBA
    isoleucine transport GO:0015818 IDA
    L-leucine transport GO:0015820 IDA
    methionine transport GO:0015821 IDA
    phenylalanine transport GO:0015823 IDA
    phenylalanine transport GO:0015823 ISS
    negative regulation of amino acid transport GO:0051956 IDA
    L-alpha-amino acid transmembrane transport GO:1902475 IEA
    negative regulation of L-leucine import across plasma membrane GO:1905533 IDA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 ISS
 Experiment description of studies that identified SLC43A2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC43A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HRH1  
Two-hybrid Homo sapiens
2 KRT35 3886
Two-hybrid Homo sapiens
3 F2RL1  
Two-hybrid Homo sapiens
4 NOTCH2NL 388677
Two-hybrid Homo sapiens
5 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 NBPF19  
Two-hybrid Homo sapiens
7 KRTAP1-3  
Two-hybrid Homo sapiens
8 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
9 CYSRT1 375791
Two-hybrid Homo sapiens
10 KRTAP1-1  
Two-hybrid Homo sapiens
11 KRTAP10-3  
Two-hybrid Homo sapiens
12 DDX58 23586
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here