Gene description for ZNF480
Gene name zinc finger protein 480
Gene symbol ZNF480
Other names/aliases -
Species Homo sapiens
 Database cross references - ZNF480
ExoCarta ExoCarta_147657
Vesiclepedia VP_147657
Entrez Gene 147657
HGNC 23305
MIM 613910
UniProt Q8WV37  
 ZNF480 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZNF480
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified ZNF480 in sEVs
1
Experiment ID 235
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZNF480
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCNDBP1 23582
Two-hybrid Homo sapiens
2 LTBP2 4053
Affinity Capture-MS Homo sapiens
3 CUL9  
Affinity Capture-MS Homo sapiens
4 KDM1A 23028
Two-hybrid Homo sapiens
5 CUL3 8452
Affinity Capture-MS Homo sapiens
6 TRIM28 10155
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ZNF467  
Affinity Capture-MS Homo sapiens
8 NOTCH2 4853
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF480 is involved
PathwayEvidenceSource
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
RNA Polymerase II Transcription TAS Reactome





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