Gene description for TM4SF1
Gene name transmembrane 4 L six family member 1
Gene symbol TM4SF1
Other names/aliases H-L6
L6
M3S1
TAAL6
Species Homo sapiens
 Database cross references - TM4SF1
ExoCarta ExoCarta_4071
Entrez Gene 4071
HGNC 11853
MIM 191155
UniProt P30408  
 TM4SF1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for TM4SF1
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    biological_process GO:0008150 ND
Subcellular Localization
    integral component of plasma membrane GO:0005887 IDA
 Experiment description of studies that identified TM4SF1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TM4SF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJA1 3301
Two-hybrid Homo sapiens
2 Tuba1a 22142
Two-hybrid Mus musculus
3 HSPA8 3312
Two-hybrid Homo sapiens
4 DDR1 780
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TM4SF1 is involved
No pathways found





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