Gene description for ANGPTL4
Gene name angiopoietin-like 4
Gene symbol ANGPTL4
Other names/aliases ANGPTL2
ARP4
FIAF
HARP
HFARP
NL2
PGAR
TGQTL
UNQ171
pp1158
Species Homo sapiens
 Database cross references - ANGPTL4
ExoCarta ExoCarta_51129
Entrez Gene 51129
HGNC 16039
MIM 605910
UniProt Q9BY76  
 ANGPTL4 identified in exosomes derived from the following tissue/cell type
Breast milk 17641064    
 Gene ontology annotations for ANGPTL4
Molecular Function
    protein binding GO:0005515 IPI
    enzyme inhibitor activity GO:0004857 ISS
Biological Process
    response to hypoxia GO:0001666 NAS
    positive regulation of angiogenesis GO:0045766 TAS
    protein homooligomerization GO:0051260 IEA
    negative regulation of lipoprotein lipase activity GO:0051005 IDA
    angiogenesis GO:0001525 IEA
    cell differentiation GO:0030154 IEA
    negative regulation of apoptotic process GO:0043066 IDA
    cellular lipid metabolic process GO:0044255 TAS
    small molecule metabolic process GO:0044281 TAS
    negative regulation of endothelial cell apoptotic process GO:2000352 IEA
    triglyceride homeostasis GO:0070328 ISS
Subcellular Localization
    extracellular space GO:0005615 IDA
    proteinaceous extracellular matrix GO:0005578 IEA
    blood microparticle GO:0072562 IDA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified ANGPTL4 in exosomes
1
Experiment ID 48
ISEV standards
EM|IEM
EV Biophysical techniques
HSC70
EV Cytosolic markers
CD63|CD86|MHCII
EV Membrane markers
CANX
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Mature milk
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for ANGPTL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ANGPTL4 is involved
PathwayEvidenceSource
PPARA activates gene expression TAS Reactome
Transcriptional regulation of white adipocyte differentiation TAS Reactome





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