Gene description for Txnl1
Gene name thioredoxin-like 1
Gene symbol Txnl1
Other names/aliases 32kDa
TRP32
Txnl
Species Mus musculus
 Database cross references - Txnl1
ExoCarta ExoCarta_53382
Vesiclepedia VP_53382
Entrez Gene 53382
UniProt Q8CDN6  
 Txnl1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Txnl1
Molecular Function
    protein-disulfide reductase activity GO:0015035 IBA
    disulfide oxidoreductase activity GO:0015036 ISO
Subcellular Localization
    proteasome complex GO:0000502 IEA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Txnl1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Txnl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Psmd8 57296
Co-fractionation Mus musculus
2 Psmc6 67089
Co-fractionation Mus musculus
3 Unk  
Affinity Capture-RNA Mus musculus
4 Rnf181  
Co-fractionation Mus musculus
5 Psmc3 19182
Co-fractionation Mus musculus
6 Psma2 19166
Co-fractionation Mus musculus
7 Psmb6 19175
Co-fractionation Mus musculus
8 Psmd4  
Co-fractionation Mus musculus
9 Psma3 19167
Co-fractionation Mus musculus
10 Psmd13 23997
Co-fractionation Mus musculus
11 Ubqln4  
Co-fractionation Mus musculus
12 Prrc2a  
Co-fractionation Mus musculus
13 Psmb1 19170
Co-fractionation Mus musculus
14 Usp14 59025
Co-fractionation Mus musculus
15 Ubqln1  
Co-fractionation Mus musculus
16 Psmd3 22123
Co-fractionation Mus musculus
17 Ufd1l  
Co-fractionation Mus musculus
18 Psmd14 59029
Co-fractionation Mus musculus
19 Psmc1 19179
Co-fractionation Mus musculus
20 Psmd1 70247
Co-fractionation Mus musculus
21 Tmem173  
Proximity Label-MS Mus musculus
22 Psmd7 17463
Co-fractionation Mus musculus
23 Fbxo7  
Co-fractionation Mus musculus
24 Psmf1  
Co-fractionation Mus musculus
25 Ublcp1  
Co-fractionation Mus musculus
26 Zfand2b  
Co-fractionation Mus musculus
27 Ubqln2  
Co-fractionation Mus musculus
28 Psmc4 23996
Co-fractionation Mus musculus
29 AI314180 230249
Co-fractionation Mus musculus
30 Rad23a  
Co-fractionation Mus musculus
31 Uchl5 56207
Co-fractionation Mus musculus
32 Psme1 19186
Co-fractionation Mus musculus
33 Prrc2c 226562
Co-fractionation Mus musculus
34 Eed  
Affinity Capture-MS Mus musculus
35 Psmd2 21762
Co-fractionation Mus musculus
36 Ube2i  
Co-fractionation Mus musculus
37 Ubfd1  
Co-fractionation Mus musculus
View the network image/svg+xml



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