Gene description for Psmd14
Gene name proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Gene symbol Psmd14
Other names/aliases 2610312C03Rik
3200001M20Rik
AA986732
Pad1
Poh1
rpm11
Species Mus musculus
 Database cross references - Psmd14
ExoCarta ExoCarta_59029
Vesiclepedia VP_59029
Entrez Gene 59029
UniProt O35593  
 Psmd14 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Psmd14
Molecular Function
    peptidase activity GO:0008233 IEA
    protein binding GO:0005515 IPI
    metallopeptidase activity GO:0008237 IEA
    proteasome binding GO:0070628 ISO
    endopeptidase activity GO:0004175 ISS
    hydrolase activity GO:0016787 IEA
    endopeptidase activator activity GO:0061133 ISO
    pyroglutamyl-peptidase activity GO:0016920 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    double-strand break repair via nonhomologous end joining GO:0006303 ISO
    double-strand break repair via homologous recombination GO:0000724 ISO
    proteolysis GO:0006508 ISS
    protein K63-linked deubiquitination GO:0070536 ISO
    regulation of proteasomal protein catabolic process GO:0061136 ISO
    positive regulation of endopeptidase activity GO:0010950 ISO
    cellular response to DNA damage stimulus GO:0006974 IEA
    DNA repair GO:0006281 IEA
Subcellular Localization
    cytosolic proteasome complex GO:0031597 ISO
    proteasome regulatory particle, lid subcomplex GO:0008541 ISO
    nucleus GO:0005634 ISO
    proteasome accessory complex GO:0022624 IDA
    extracellular exosome GO:0070062 ISO
    proteasome complex GO:0000502 ISS
 Experiment description of studies that identified Psmd14 in exosomes
1
Experiment ID 210
MISEV standards
EM
EV Biophysical techniques
CD81|FLOT1
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Psmd14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Psmd14 is involved
PathwayEvidenceSource
Activation of NF-kappaB in B cells IEA Reactome
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome
APC/C:Cdc20 mediated degradation of Securin IEA Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 IEA Reactome
Asymmetric localization of PCP proteins IEA Reactome
AUF1 (hnRNP D0) destabilizes mRNA IEA Reactome
Autodegradation of Cdh1 by Cdh1:APC/C IEA Reactome
Autodegradation of the E3 ubiquitin ligase COP1 IEA Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A IEA Reactome
CDK-mediated phosphorylation and removal of Cdc6 IEA Reactome
CDK-mediated phosphorylation and removal of Cdc6 IEA Reactome
CDT1 association with the CDC6:ORC:origin complex IEA Reactome
CLEC7A (Dectin-1) signaling IEA Reactome
Cross-presentation of soluble exogenous antigens (endosomes) IEA Reactome
Dectin-1 mediated noncanonical NF-kB signaling IEA Reactome
degradation of AXIN IEA Reactome
Degradation of beta-catenin by the destruction complex IEA Reactome
degradation of DVL IEA Reactome
Degradation of GLI1 by the proteasome IEA Reactome
Degradation of GLI2 by the proteasome IEA Reactome
ER-Phagosome pathway IEA Reactome
GLI3 is processed to GLI3R by the proteasome IEA Reactome
Hedgehog 'on' state IEA Reactome
Hedgehog ligand biogenesis IEA Reactome
Orc1 removal from chromatin IEA Reactome
Orc1 removal from chromatin IEA Reactome
Regulation of activated PAK-2p34 by proteasome mediated degradation IEA Reactome
Regulation of ornithine decarboxylase (ODC) IEA Reactome
SCF(Skp2)-mediated degradation of p27/p21 IEA Reactome
SCF(Skp2)-mediated degradation of p27/p21 IEA Reactome
SCF-beta-TrCP mediated degradation of Emi1 IEA Reactome
Separation of Sister Chromatids IEA Reactome
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A IEA Reactome
Ubiquitin-dependent degradation of Cyclin D1 IEA Reactome





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