Gene description for Psme2
Gene name proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Gene symbol Psme2
Other names/aliases AA589371
AI788882
PA28b
Species Mus musculus
 Database cross references - Psme2
ExoCarta ExoCarta_19188
Vesiclepedia VP_19188
Entrez Gene 19188
UniProt P97372  
 Psme2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Psme2
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
    endopeptidase activator activity GO:0061133 IDA
Biological Process
    antigen processing and presentation of exogenous antigen GO:0019884 IMP
    regulation of proteasomal protein catabolic process GO:0061136 IBA
    regulation of G1/S transition of mitotic cell cycle GO:2000045 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IBA
    cytoplasm GO:0005737 IBA
    proteasome activator complex GO:0008537 IEA
 Experiment description of studies that identified Psme2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Psme2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Psmb7 19177
Co-fractionation Mus musculus
2 Psmc6 67089
Co-fractionation Mus musculus
3 Psmd2 21762
Co-fractionation Mus musculus
4 Psmc3 19182
Co-fractionation Mus musculus
5 Psma2 19166
Co-fractionation Mus musculus
6 Psmc2 19181
Co-fractionation Mus musculus
7 Psmd4  
Co-fractionation Mus musculus
8 Psma3 19167
Co-fractionation Mus musculus
9 Psmd13 23997
Co-fractionation Mus musculus
10 Psmb1 19170
Co-fractionation Mus musculus
11 Atxn1  
Affinity Capture-MS Mus musculus
12 Vcp 269523
Co-fractionation Mus musculus
13 Psme3 19192
Co-fractionation Mus musculus
14 Psmd14 59029
Co-fractionation Mus musculus
15 Psmb8 16913
Co-fractionation Mus musculus
16 Psmc5 19184
Co-fractionation Mus musculus
17 Psmd9  
Co-fractionation Mus musculus
18 Psmc1 19179
Co-fractionation Mus musculus
19 Psmd5 66998
Co-fractionation Mus musculus
20 Tmem173  
Proximity Label-MS Mus musculus
21 Psmd7 17463
Co-fractionation Mus musculus
22 Psmc4 23996
Co-fractionation Mus musculus
23 Psmd3 22123
Co-fractionation Mus musculus
24 Psme1 19186
Co-fractionation Mus musculus
Co-fractionation Mus musculus
25 Psmb2 26445
Co-fractionation Mus musculus
26 Psmd6 66413
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Psme2 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Post-translational protein modification IEA Reactome
Proteasome assembly IEA Reactome





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