Gene description for Rab11a
Gene name RAB11A, member RAS oncogene family
Gene symbol Rab11a
Other names/aliases -
Species Mus musculus
 Database cross references - Rab11a
ExoCarta ExoCarta_53869
Entrez Gene 53869
UniProt P62492  
 Rab11a identified in exosomes derived from the following tissue/cell type
Embryonic fibroblasts 18494037    
Microglia 16081791    
Pancreatic cells 19351151    
 Gene ontology annotations for Rab11a
Molecular Function
    myosin V binding GO:0031489 ISO
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 ISO
    GTPase activity GO:0003924 ISO
    nucleotide binding GO:0000166 IEA
    microtubule binding GO:0008017 ISO
Biological Process
    mitotic metaphase plate congression GO:0007080 ISO
    vesicle-mediated transport GO:0016192 ISO
    positive regulation of epithelial cell migration GO:0010634 ISO
    melanosome transport GO:0032402 IMP
    mitotic spindle assembly GO:0090307 ISO
    establishment of vesicle localization GO:0051650 ISO
    neuron projection development GO:0031175 ISO
    establishment of protein localization to membrane GO:0090150 ISO
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 ISO
    astral microtubule organization GO:0030953 ISO
    exocytosis GO:0006887 IBA
    small GTPase mediated signal transduction GO:0007264 IEA
    regulation of long-term neuronal synaptic plasticity GO:0048169 ISO
    regulation of protein transport GO:0051223 ISO
    establishment of protein localization to organelle GO:0072594 ISO
    intracellular protein transport GO:0006886 IBA
    transport GO:0006810 IEA
    protein transport GO:0015031 IEA
    positive regulation of axon extension GO:0045773 IMP
    Rab protein signal transduction GO:0032482 IBA
    multivesicular body assembly GO:0036258 ISO
    regulation of vesicle-mediated transport GO:0060627 ISO
    regulation of multivesicular body size GO:0010796 ISO
    protein localization to plasma membrane GO:0072659 ISO
    cell cycle GO:0007049 IEA
    cytokinesis GO:0000910 ISO
    exosomal secretion GO:1990182 ISO
    metabolic process GO:0008152 ISO
Subcellular Localization
    vesicle GO:0031982 ISO
    extracellular exosome GO:0070062 ISO
    kinetochore microtubule GO:0005828 ISO
    protein complex GO:0043234 ISO
    axon GO:0030424 IDA
    phagocytic vesicle GO:0045335 ISO
    multivesicular body GO:0005771 ISO
    cytoplasmic vesicle GO:0031410 ISO
    endosome GO:0005768 IEA
    membrane GO:0016020 IDA
    cleavage furrow GO:0032154 ISO
    cytoplasm GO:0005737 IDA
    spindle pole GO:0000922 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
    trans-Golgi network GO:0005802 ISO
    intracellular GO:0005622 IBA
    mitochondrion GO:0005739 IDA
    Golgi apparatus GO:0005794 ISO
    recycling endosome GO:0055037 ISO
    transport vesicle GO:0030133 ISO
    cell GO:0005623 IMP
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Rab11a in exosomes
1
Experiment ID 73
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
2
Experiment ID 14
ISEV standards
✔
EM
EV Biophysical techniques
✔
RAB7|RAB11
EV Cytosolic markers
✔
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
✔
DNM
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
3
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Rab11a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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