Gene description for PROC
Gene name protein C (inactivator of coagulation factors Va and VIIIa)
Gene symbol PROC
Other names/aliases APC
PC
PROC1
THPH3
THPH4
Species Homo sapiens
 Database cross references - PROC
ExoCarta ExoCarta_5624
Vesiclepedia VP_5624
Entrez Gene 5624
HGNC 9451
MIM 612283
UniProt P04070  
 PROC identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for PROC
Molecular Function
    calcium ion binding GO:0005509 IEA
    serine-type endopeptidase activity GO:0004252 TAS
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of blood coagulation GO:0030195 TAS
    cellular protein metabolic process GO:0044267 TAS
    peptidyl-glutamic acid carboxylation GO:0017187 TAS
    proteolysis GO:0006508 TAS
    leukocyte migration GO:0050900 TAS
    post-translational protein modification GO:0043687 TAS
    blood coagulation GO:0007596 TAS
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 TAS
    extracellular region GO:0005576 TAS
    Golgi lumen GO:0005796 TAS
 Experiment description of studies that identified PROC in exosomes
1
Experiment ID 497
MISEV standards
✘ EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PROC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F2 2147
Invitro Homo sapiens
2 PROC 5624
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PROCR 10544
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
4 SERPINB6 5269
Affinity Capture-MS Homo sapiens
5 SERPINA5 5104
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
6 PROS1 5627
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
7 CP 1356
Invitro Homo sapiens
8 F5 2153
Invitro Homo sapiens
9 F8 2157
Affinity Capture-MS Homo sapiens
10 PF4 5196
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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