Gene description for RETN
Gene name resistin
Gene symbol RETN
Other names/aliases ADSF
FIZZ3
RETN1
RSTN
XCP1
Species Homo sapiens
 Database cross references - RETN
ExoCarta ExoCarta_56729
Vesiclepedia VP_56729
Entrez Gene 56729
HGNC 20389
MIM 605565
UniProt Q9HD89  
 RETN identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for RETN
Molecular Function
    hormone activity GO:0005179 IEA
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 IEA
    response to mechanical stimulus GO:0009612 IEA
    response to insulin GO:0032868 IEA
    fat cell differentiation GO:0045444 IEA
    positive regulation of synaptic transmission GO:0050806 IEA
    negative regulation of feeding behavior GO:2000252 IEA
    positive regulation of progesterone secretion GO:2000872 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    azurophil granule lumen GO:0035578 TAS
    specific granule lumen GO:0035580 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified RETN in sEVs
1
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for RETN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 A2M 2
Two-hybrid Homo sapiens
2 GPR25  
Two-hybrid Homo sapiens
3 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 APEX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SQSTM1 8878
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZNF664  
Affinity Capture-MS Homo sapiens
7 EGFR 1956
Negative Genetic Homo sapiens
8 RETN 56729
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 GLI4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DDX58 23586
Affinity Capture-RNA Homo sapiens
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