Gene description for RETN
Gene name resistin
Gene symbol RETN
Other names/aliases ADSF
FIZZ3
RETN1
RSTN
XCP1
Species Homo sapiens
 Database cross references - RETN
ExoCarta ExoCarta_56729
Entrez Gene 56729
HGNC 20389
MIM 605565
UniProt Q9HD89  
 RETN identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for RETN
Molecular Function
    hormone activity GO:0005179 IEA
Biological Process
    positive regulation of collagen metabolic process GO:0010714 IEA
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    negative regulation of feeding behavior GO:2000252 IEA
    positive regulation of smooth muscle cell migration GO:0014911 IEA
    response to insulin GO:0032868 IEA
    positive regulation of progesterone secretion GO:2000872 IEA
    aging GO:0007568 IEA
    response to mechanical stimulus GO:0009612 IEA
    fat cell differentiation GO:0045444 IEA
    positive regulation of synaptic transmission GO:0050806 IEA
    biological_process GO:0008150 ND
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified RETN in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for RETN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RETN 56729
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which RETN is involved
No pathways found





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