Gene description for ABHD6
Gene name abhydrolase domain containing 6
Gene symbol ABHD6
Other names/aliases -
Species Homo sapiens
 Database cross references - ABHD6
ExoCarta ExoCarta_57406
Vesiclepedia VP_57406
Entrez Gene 57406
HGNC 21398
UniProt Q9BV23  
 ABHD6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ABHD6
Molecular Function
    phospholipase activity GO:0004620 IEA
    protein binding GO:0005515 IPI
    monoacylglycerol lipase activity GO:0047372 IBA
    monoacylglycerol lipase activity GO:0047372 IDA
    monoacylglycerol lipase activity GO:0047372 TAS
Biological Process
    phospholipid catabolic process GO:0009395 IEA
    arachidonate metabolic process GO:0019369 TAS
    negative regulation of cell migration GO:0030336 IEA
    acylglycerol catabolic process GO:0046464 IBA
    acylglycerol catabolic process GO:0046464 IDA
    positive regulation of lipid biosynthetic process GO:0046889 IEA
    monoacylglycerol catabolic process GO:0052651 ISS
    long-term synaptic depression GO:0060292 IEA
    regulation of retrograde trans-synaptic signaling by endocanabinoid GO:0099178 IEA
    negative regulation of cold-induced thermogenesis GO:0120163 ISS
    regulation of endocannabinoid signaling pathway GO:2000124 IEA
    lysobisphosphatidic acid metabolic process GO:2001311 ISS
Subcellular Localization
    lysosomal membrane GO:0005765 ISS
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IBA
    membrane GO:0016020 ISS
    late endosome membrane GO:0031902 ISS
    mitochondrial membrane GO:0031966 IEA
    AMPA glutamate receptor complex GO:0032281 IBA
    postsynaptic membrane GO:0045211 IEA
    glutamatergic synapse GO:0098978 IEA
    GABA-ergic synapse GO:0098982 IEA
 Experiment description of studies that identified ABHD6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ABHD6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 OR10H1  
Affinity Capture-MS Homo sapiens
3 KIF14 9928
Affinity Capture-MS Homo sapiens
4 TTYH1  
Affinity Capture-MS Homo sapiens
5 CKMT2  
Two-hybrid Homo sapiens
6 RXFP1  
Affinity Capture-MS Homo sapiens
7 OR10H2  
Affinity Capture-MS Homo sapiens
8 RTP2  
Two-hybrid Homo sapiens
9 NPTN 27020
Affinity Capture-MS Homo sapiens
10 TVP23B  
Two-hybrid Homo sapiens
11 IGHM 3507
Affinity Capture-MS Homo sapiens
12 PCDHA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 FSHR  
Affinity Capture-MS Homo sapiens
14 PCGF2 7703
Two-hybrid Homo sapiens
15 FIS1 51024
Two-hybrid Homo sapiens
16 PCDHGC4  
Affinity Capture-MS Homo sapiens
17 NCS1 23413
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MARCH4  
Affinity Capture-MS Homo sapiens
19 Ufl1  
Affinity Capture-MS Mus musculus
20 HPCA 3208
Affinity Capture-MS Homo sapiens
21 C3orf52  
Affinity Capture-MS Homo sapiens
22 SCAMP4 113178
Two-hybrid Homo sapiens
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