Gene description for CALB1
Gene name calbindin 1, 28kDa
Gene symbol CALB1
Other names/aliases CALB
D-28K
Species Homo sapiens
 Database cross references - CALB1
ExoCarta ExoCarta_793
Entrez Gene 793
HGNC 1434
MIM 114050
UniProt P05937  
 CALB1 identified in exosomes derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for CALB1
Molecular Function
    zinc ion binding GO:0008270 IMP
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IMP
    vitamin D binding GO:0005499 IEA
Biological Process
    cytosolic calcium ion homeostasis GO:0051480 IEA
    metanephric part of ureteric bud development GO:0035502 IEA
    metanephric connecting tubule development GO:0072286 IEA
    locomotory behavior GO:0007626 IEA
    long-term memory GO:0007616 IMP
    metanephric distal convoluted tubule development GO:0072221 IEA
    regulation of synaptic plasticity GO:0048167 IEA
    short-term memory GO:0007614 IMP
    retina layer formation GO:0010842 IEA
    metanephric collecting duct development GO:0072205 IEA
    cellular response to organic substance GO:0071310 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    synapse GO:0045202 IEA
    nucleus GO:0005634 IDA
    axon GO:0030424 ISS
    neuronal cell body GO:0043025 IDA
    dendrite GO:0030425 IDA
    cytosol GO:0005829 IEA
 Experiment description of studies that identified CALB1 in exosomes
1
Experiment ID 13
ISEV standards
IEM
EV Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101
EV Cytosolic markers
CD9|AQP2|AQP1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors Pisitkun T, Shen RF, Knepper MA
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
3
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CALB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RANBP9 10048
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 IMPA1 3612
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CALB1 is involved
No pathways found





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