Gene description for HMCN1
Gene name hemicentin 1
Gene symbol HMCN1
Other names/aliases ARMD1
FBLN6
FIBL-6
FIBL6
Species Homo sapiens
 Database cross references - HMCN1
ExoCarta ExoCarta_83872
Entrez Gene 83872
HGNC 19194
MIM 608548
UniProt Q96RW7  
 HMCN1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for HMCN1
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    response to stimulus GO:0050896 IEA
    visual perception GO:0007601 IEA
Subcellular Localization
    cell junction GO:0030054 IEA
    extracellular matrix GO:0031012 TAS
    cell cortex GO:0005938 IEA
    basement membrane GO:0005604 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified HMCN1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for HMCN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HMCN1 is involved
No pathways found





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