Gene description for SYTL5
Gene name synaptotagmin-like 5
Gene symbol SYTL5
Other names/aliases slp5
Species Homo sapiens
 Database cross references - SYTL5
ExoCarta ExoCarta_94122
Entrez Gene 94122
HGNC 15589
UniProt Q8TDW5  
 SYTL5 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SYTL5
Molecular Function
    Rab GTPase binding GO:0017137 IEA
    protein binding GO:0005515 IPI
    clathrin binding GO:0030276 IBA
    calcium ion binding GO:0005509 IBA
    calcium-dependent phospholipid binding GO:0005544 IBA
    syntaxin binding GO:0019905 IBA
Biological Process
    intracellular protein transport GO:0006886 IEA
    synaptic vesicle exocytosis GO:0016079 IBA
    regulation of calcium ion-dependent exocytosis GO:0017158 IBA
    calcium ion-dependent exocytosis of neurotransmitter GO:0048791 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    exocytic vesicle GO:0070382 IBA
 Experiment description of studies that identified SYTL5 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SYTL5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB27A 5873
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
2 RAB6A 5870
Invivo Homo sapiens
Invitro Homo sapiens
3 RAB3A 5864
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SYTL5 is involved
No pathways found

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