Gene description for Nedd4l
Gene name neural precursor cell expressed, developmentally down-regulated gene 4-like
Gene symbol Nedd4l
Other names/aliases 1300012C07Rik
Nedd4-2
Nedd4b
Species Mus musculus
 Database cross references - Nedd4l
ExoCarta ExoCarta_83814
Vesiclepedia VP_83814
Entrez Gene 83814
 Nedd4l identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Nedd4l
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISO
    protein binding GO:0005515 IPI
    potassium channel regulator activity GO:0015459 ISO
    sodium channel regulator activity GO:0017080 ISO
    potassium channel inhibitor activity GO:0019870 ISO
    sodium channel inhibitor activity GO:0019871 IBA
    sodium channel inhibitor activity GO:0019871 IDA
    sodium channel inhibitor activity GO:0019871 ISO
    transmembrane transporter binding GO:0044325 ISO
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    regulation of sodium ion transport GO:0002028 IDA
    negative regulation of systemic arterial blood pressure GO:0003085 IMP
    regulation of membrane depolarization GO:0003254 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    protein monoubiquitination GO:0006513 ISO
    sodium ion transport GO:0006814 IMP
    neuromuscular junction development GO:0007528 IBA
    response to salt stress GO:0009651 IMP
    positive regulation of sodium ion transport GO:0010765 IGI
    negative regulation of sodium ion transport GO:0010766 IDA
    negative regulation of sodium ion transport GO:0010766 IMP
    negative regulation of sodium ion transport GO:0010766 ISO
    protein ubiquitination GO:0016567 IEA
    protein ubiquitination GO:0016567 ISO
    protein ubiquitination GO:0016567 ISS
    cell differentiation GO:0030154 IEA
    neuron projection development GO:0031175 IBA
    receptor internalization GO:0031623 IBA
    regulation of protein stability GO:0031647 ISO
    regulation of protein stability GO:0031647 ISS
    receptor catabolic process GO:0032801 IBA
    regulation of monoatomic ion transmembrane transport GO:0034765 ISO
    regulation of membrane potential GO:0042391 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    positive regulation of protein catabolic process GO:0045732 ISO
    regulation of dendrite morphogenesis GO:0048814 IBA
    regulation of synapse organization GO:0050807 IBA
    establishment of localization in cell GO:0051649 IMP
    regulation of membrane repolarization GO:0060306 ISO
    protein K48-linked ubiquitination GO:0070936 ISO
    ventricular cardiac muscle cell action potential GO:0086005 ISO
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IDA
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IEP
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IMP
    regulation protein catabolic process at postsynapse GO:0140252 IDA
    regulation protein catabolic process at postsynapse GO:0140252 IEP
    regulation protein catabolic process at postsynapse GO:0140252 IMP
    regulation of potassium ion transmembrane transporter activity GO:1901016 ISO
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 ISO
    negative regulation of potassium ion transmembrane transport GO:1901380 ISO
    regulation of sodium ion transmembrane transport GO:1902305 ISO
    regulation of sodium ion transmembrane transport GO:1902305 ISS
    negative regulation of sodium ion transmembrane transport GO:1902306 ISO
    positive regulation of dendrite extension GO:1903861 ISO
    negative regulation of protein localization to cell surface GO:2000009 ISO
    negative regulation of sodium ion transmembrane transporter activity GO:2000650 ISO
    regulation of bicellular tight junction assembly GO:2000810 IDA
    positive regulation of cation channel activity GO:2001259 IGI
    positive regulation of caveolin-mediated endocytosis GO:2001288 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    multivesicular body GO:0005771 IEA
    Golgi apparatus GO:0005794 IEA
    plasma membrane GO:0005886 ISO
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Nedd4l in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Nedd4l
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tnik  
Affinity Capture-MS Mus musculus
2 AQP2 359
Affinity Capture-Western Homo sapiens
3 Dpysl2 12934
Affinity Capture-Western Mus musculus
4 Dlgap1  
Affinity Capture-MS Mus musculus
5 Dlg3  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
6 N4bp1  
Biochemical Activity Mus musculus
7 Scnn1b  
Affinity Capture-Western Mus musculus
Far Western Mus musculus
8 Scnn1g  
Far Western Mus musculus
9 Kctd13  
Affinity Capture-MS Mus musculus
10 Dlg4  
Affinity Capture-MS Mus musculus
11 Shank3  
Affinity Capture-MS Mus musculus
12 UBE2E1  
Reconstituted Complex Homo sapiens
13 Scnn1a  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Far Western Mus musculus
14 Sgk1  
Affinity Capture-Western Mus musculus
15 Sfn 55948
Affinity Capture-Western Mus musculus
16 LPAR1 1902
Affinity Capture-Western Homo sapiens
17 Ywhaq 22630
Affinity Capture-Western Mus musculus
18 Adrbk1 110355
Biochemical Activity Mus musculus
Affinity Capture-Western Mus musculus
19 Lpar1  
Affinity Capture-Western Mus musculus
20 Slc12a3  
Affinity Capture-Western Rattus norvegicus
21 Ywhab 54401
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
22 Pfkp 56421
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
23 LDLRAD3  
Reconstituted Complex Homo sapiens
24 Wnk1 232341
Affinity Capture-Western Mus musculus
25 UBE2L3 7332
Reconstituted Complex Homo sapiens
26 WNK3  
Reconstituted Complex Homo sapiens
Phenotypic Suppression Homo sapiens
Phenotypic Enhancement Homo sapiens
27 Nedd4l 83814
Biochemical Activity Mus musculus
Biochemical Activity Mus musculus
28 UBE2D2 7322
Reconstituted Complex Homo sapiens
29 Ywhae 22627
Affinity Capture-Western Mus musculus
30 Ndfip1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
31 Slc12a1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
32 Ywhag 22628
Affinity Capture-Western Mus musculus
33 UBE2D1 7321
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which Nedd4l is involved
No pathways found





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