Gene description for ABI2
Gene name abl-interactor 2
Gene symbol ABI2
Other names/aliases ABI-2
ABI2B
AIP-1
AblBP3
SSH3BP2
argBP1
argBPIA
argBPIB
Species Homo sapiens
 Database cross references - ABI2
ExoCarta ExoCarta_10152
Vesiclepedia VP_10152
Entrez Gene 10152
HGNC 24011
MIM 606442
UniProt Q9NYB9  
 ABI2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ABI2
Molecular Function
    protein binding GO:0005515 IPI
    cytoskeletal anchor activity GO:0008093 TAS
    SH3 domain binding GO:0017124 IPI
    SH3 domain binding GO:0017124 TAS
    kinase binding GO:0019900 NAS
    small GTPase binding GO:0031267 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
    signaling adaptor activity GO:0035591 IBA
    signaling adaptor activity GO:0035591 IDA
    identical protein binding GO:0042802 IPI
    proline-rich region binding GO:0070064 IPI
Biological Process
    mitophagy GO:0000423 IDA
    neuron migration GO:0001764 IBA
    cytoskeleton organization GO:0007010 TAS
    actin polymerization or depolymerization GO:0008154 NAS
    positive regulation of lamellipodium assembly GO:0010592 IDA
    cell migration GO:0016477 TAS
    Rac protein signal transduction GO:0016601 IDA
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    zonula adherens assembly GO:0045186 IMP
    cell projection morphogenesis GO:0048858 IBA
    regulation of dendritic spine morphogenesis GO:0061001 ISS
    lens fiber cell morphogenesis GO:0070309 ISS
    positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 IDA
    cytoskeleton GO:0005856 IEA
    actin filament GO:0005884 IDA
    adherens junction GO:0005912 IDA
    adherens junction GO:0005912 IEA
    lamellipodium GO:0030027 IBA
    lamellipodium GO:0030027 IDA
    SCAR complex GO:0031209 IBA
    SCAR complex GO:0031209 IDA
    filopodium tip GO:0032433 IDA
    dendritic spine GO:0043197 ISS
    actin-based cell projection GO:0098858 IBA
 Experiment description of studies that identified ABI2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ABI2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMA1 5682
Two-hybrid Homo sapiens
2 HOMER3 9454
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
3 PRKAA1 5562
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 APPL2 55198
Co-fractionation Homo sapiens
5 PPP3CA 5530
Two-hybrid Homo sapiens
6 TNIP1 10318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HOOK1  
Proximity Label-MS Homo sapiens
8 KLC2 64837
Affinity Capture-MS Homo sapiens
9 Caskin1  
Two-hybrid Rattus norvegicus
10 BLOC1S6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 SNAP23 8773
Two-hybrid Homo sapiens
12 CASC1  
Two-hybrid Homo sapiens
13 CCDC36  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 SIKE1  
Affinity Capture-MS Homo sapiens
15 KIFC3 3801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 WASF2 10163
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 AES 166
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 TPM2 7169
Two-hybrid Homo sapiens
19 YWHAE 7531
Affinity Capture-MS Homo sapiens
20 C19orf54  
Two-hybrid Homo sapiens
21 NUP62 23636
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 CAP1 10487
Co-fractionation Homo sapiens
23 GFAP 2670
Two-hybrid Homo sapiens
24 DISC1 27185
Two-hybrid Homo sapiens
25 MAGEA1  
Two-hybrid Homo sapiens
26 ENKD1  
Two-hybrid Homo sapiens
27 NCKIPSD 51517
Two-hybrid Homo sapiens
28 CENPH  
Two-hybrid Homo sapiens
29 RASD1  
Two-hybrid Homo sapiens
30 C20orf202  
Two-hybrid Homo sapiens
31 STX4 6810
Two-hybrid Homo sapiens
32 CCDC102B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 VASP 7408
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 ADAM19 8728
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
35 ABL2  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
36 ARMC7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 LMO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 RAPH1 65059
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 MRFAP1L1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 RNPS1 10921
Two-hybrid Homo sapiens
41 NCKAP1L 3071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SNAPIN 23557
Two-hybrid Homo sapiens
43 FAM166B  
Two-hybrid Homo sapiens
44 SHMT2 6472
Affinity Capture-RNA Homo sapiens
45 LENG1  
Two-hybrid Homo sapiens
46 HGS 9146
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
47 DLGAP2  
Two-hybrid Homo sapiens
48 KHDRBS1 10657
Protein-peptide Homo sapiens
49 OIP5  
Two-hybrid Homo sapiens
50 ABI1 10006
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TFIP11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 BRK1 55845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 WASH1 100287171
Two-hybrid Homo sapiens
54 KRT31 3881
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
55 NHS 4810
Affinity Capture-MS Homo sapiens
56 CCDC53 51019
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
57 WASL 8976
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
58 YWHAH 7533
Affinity Capture-MS Homo sapiens
59 CCDC115 84317
Two-hybrid Homo sapiens
60 CEP57  
Two-hybrid Homo sapiens
61 LHX4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 PHF1  
Two-hybrid Homo sapiens
63 FSD2 123722
Affinity Capture-MS Homo sapiens
64 TIMM50 92609
Affinity Capture-MS Homo sapiens
65 LMO1  
Two-hybrid Homo sapiens
66 KNSTRN  
Two-hybrid Homo sapiens
67 SDCBP 6386
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 NCK1 4690
Affinity Capture-MS Homo sapiens
69 SLA  
Two-hybrid Homo sapiens
70 WASF3 10810
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 PRR20C  
Two-hybrid Homo sapiens
72 CGB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 IFT20 90410
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
74 C1orf216  
Two-hybrid Homo sapiens
75 EGR4  
Two-hybrid Homo sapiens
76 YWHAB 7529
Affinity Capture-MS Homo sapiens
77 WIPF1 7456
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 PWWP2B  
Two-hybrid Homo sapiens
79 RABGEF1 27342
Two-hybrid Homo sapiens
80 SPAG5 10615
Affinity Capture-MS Homo sapiens
81 KIAA1217 56243
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
82 STAM2 10254
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
83 OOEP  
Two-hybrid Homo sapiens
84 KRT34  
Two-hybrid Homo sapiens
85 ARHGAP12  
Affinity Capture-MS Homo sapiens
86 FHL5 9457
Two-hybrid Homo sapiens
87 TRIML2  
Two-hybrid Homo sapiens
88 MYO15B 80022
Two-hybrid Homo sapiens
89 IKBIP 121457
Affinity Capture-MS Homo sapiens
90 FAM161B  
Two-hybrid Homo sapiens
91 WASF1 8936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 PAK2 5062
Two-hybrid Homo sapiens
93 MYOZ3  
Two-hybrid Homo sapiens
94 PARK2  
Affinity Capture-MS Homo sapiens
95 KRT24 192666
Two-hybrid Homo sapiens
96 FAM9C  
Two-hybrid Homo sapiens
97 MCAM 4162
Proximity Label-MS Homo sapiens
98 VPS28 51160
Two-hybrid Homo sapiens
99 FOXD4L1  
Two-hybrid Homo sapiens
100 C10orf88  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 CASKIN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 CCDC57 284001
Two-hybrid Homo sapiens
103 BLOC1S5 63915
Two-hybrid Homo sapiens
104 PTPRE 5791
Proximity Label-MS Homo sapiens
105 VCL 7414
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
106 DTNB 1838
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
107 NTRK1 4914
Affinity Capture-MS Homo sapiens
108 MYOG  
Two-hybrid Homo sapiens
109 PLEKHN1  
Two-hybrid Homo sapiens
110 LHX3  
Two-hybrid Homo sapiens
111 LHX8  
Two-hybrid Homo sapiens
112 KRT14 3861
Two-hybrid Homo sapiens
113 MEOX2  
Two-hybrid Homo sapiens
114 BICD2 23299
Proximity Label-MS Homo sapiens
115 COG3 83548
Two-hybrid Homo sapiens
116 ENO1 2023
Affinity Capture-RNA Homo sapiens
117 PRR20E  
Two-hybrid Homo sapiens
118 CCDC22 28952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 GCC1 79571
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
120 EIF3H 8667
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
121 CCDC74B  
Two-hybrid Homo sapiens
122 ZNF474  
Two-hybrid Homo sapiens
123 ENAH 55740
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
124 MPDZ  
Affinity Capture-MS Homo sapiens
125 OGT 8473
Reconstituted Complex Homo sapiens
126 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
127 MRPL44  
Two-hybrid Homo sapiens
128 ABI3 51225
Two-hybrid Homo sapiens
129 ARHGAP32  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
130 KRT33B 3884
Two-hybrid Homo sapiens
131 ANKRD55  
Two-hybrid Homo sapiens
132 EGLN3  
Two-hybrid Homo sapiens
133 NCKAP1 10787
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 TRAF3IP1 26146
Two-hybrid Homo sapiens
135 PRKAA2 5563
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
136 PRR20D  
Two-hybrid Homo sapiens
137 KRT75 9119
Two-hybrid Homo sapiens
138 SNX18 112574
Two-hybrid Homo sapiens
139 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 EFS  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
141 LGALS9B 284194
Two-hybrid Homo sapiens
142 NHSL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 HOOK3 84376
Proximity Label-MS Homo sapiens
144 FAM90A1  
Two-hybrid Homo sapiens
145 SNX7 51375
Two-hybrid Homo sapiens
146 VARS2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
147 CYFIP2 26999
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 XRCC6BP1  
Two-hybrid Homo sapiens
149 SASS6 163786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 KRT27 342574
Two-hybrid Homo sapiens
151 NXF1 10482
Affinity Capture-RNA Homo sapiens
152 CRX  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
153 CUEDC1 404093
Two-hybrid Homo sapiens
154 LZTS2 84445
Two-hybrid Homo sapiens
155 KRT15 3866
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
156 ABLIM3 22885
Two-hybrid Homo sapiens
157 PRR20B  
Two-hybrid Homo sapiens
158 TPM1 7168
Co-fractionation Homo sapiens
159 TRIM32 22954
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
160 RPP25  
Two-hybrid Homo sapiens
161 POMC  
Two-hybrid Homo sapiens
162 EPS8L1 54869
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
163 AMZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 RGPD5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 INO80B 83444
Two-hybrid Homo sapiens
166 SCGN  
Affinity Capture-MS Homo sapiens
167 MRFAP1  
Two-hybrid Homo sapiens
168 HSPA1A 3303
Affinity Capture-MS Homo sapiens
169 EXOC7 23265
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 SORBS3 10174
Two-hybrid Homo sapiens
171 BICD1 636
Proximity Label-MS Homo sapiens
172 ACTB 60
Affinity Capture-MS Homo sapiens
173 GAS2L2  
Two-hybrid Homo sapiens
174 USHBP1  
Two-hybrid Homo sapiens
175 PCM1 5108
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
176 PTPRU  
Proximity Label-MS Homo sapiens
177 KRT19 3880
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
178 BAIAP2 10458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 PFDN5 5204
Two-hybrid Homo sapiens
180 BAG4  
Two-hybrid Homo sapiens
181 KIAA1522 57648
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 PPIF 10105
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
183 CBLC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 MED11  
Two-hybrid Homo sapiens
185 Nhsl1  
Affinity Capture-MS Mus musculus
186 CLPP 8192
Two-hybrid Homo sapiens
187 TRIP6 7205
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
188 UBQLN2 29978
Two-hybrid Homo sapiens
189 PDLIM7 9260
Two-hybrid Homo sapiens
190 STX19  
Two-hybrid Homo sapiens
191 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
192 GRN 2896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 HHEX  
Two-hybrid Homo sapiens
194 KRT36 8689
Two-hybrid Homo sapiens
195 PRR20A  
Two-hybrid Homo sapiens
196 GGN  
Two-hybrid Homo sapiens
197 PRDM14  
Two-hybrid Homo sapiens
198 TRIM72  
Two-hybrid Homo sapiens
199 CCHCR1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
200 WWOX 51741
Two-hybrid Homo sapiens
201 PCMT1 5110
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 PIN1 5300
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
203 INCA1  
Two-hybrid Homo sapiens
204 ZNF511  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 LMO4  
Two-hybrid Homo sapiens
206 ABL1 25
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 DCTN2 10540
Two-hybrid Homo sapiens
208 FAM109A  
Two-hybrid Homo sapiens
209 UBR3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 UBXN11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
211 CDK6 1021
Biochemical Activity Homo sapiens
212 C15orf59  
Two-hybrid Homo sapiens
213 GPANK1  
Two-hybrid Homo sapiens
214 HNRNPK 3190
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
215 PRAM1  
Two-hybrid Homo sapiens
216 NCK2 8440
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
217 CEP44  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
218 ZFP90  
Two-hybrid Homo sapiens
219 MED10  
Two-hybrid Homo sapiens
220 SPG11 80208
Affinity Capture-MS Homo sapiens
221 ACTG1 71
Affinity Capture-MS Homo sapiens
222 ABI2 10152
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
223 NME4 4833
Two-hybrid Homo sapiens
224 TCF4  
Affinity Capture-MS Homo sapiens
225 MOV10 4343
Affinity Capture-RNA Homo sapiens
226 KRT20 54474
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
227 FGFR1OP2  
Affinity Capture-MS Homo sapiens
228 ZNF688  
Two-hybrid Homo sapiens
229 NFASC 23114
Two-hybrid Homo sapiens
230 RUSC1  
Two-hybrid Homo sapiens
231 C1orf109  
Two-hybrid Homo sapiens
232 BIN3 55909
Two-hybrid Homo sapiens
233 EPHA2 1969
Proximity Label-MS Homo sapiens
234 KRT13 3860
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
235 KRAS 3845
Proximity Label-MS Homo sapiens
236 CYFIP1 23191
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
237 NHSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
238 C4orf17  
Two-hybrid Homo sapiens
239 HSF2BP  
Two-hybrid Homo sapiens
240 PRR16  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
241 LURAP1  
Two-hybrid Homo sapiens
242 AKAP9 10142
Two-hybrid Homo sapiens
243 KIAA0355 9710
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
244 C17orf59 54785
Two-hybrid Homo sapiens
245 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ABI2 is involved
PathwayEvidenceSource
Disease TAS Reactome
Disease IEA Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis IEA Reactome
FCGR3A-mediated phagocytosis TAS Reactome
FCGR3A-mediated phagocytosis IEA Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Infectious disease IEA Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Leishmania infection TAS Reactome
Leishmania infection IEA Reactome
Leishmania phagocytosis TAS Reactome
Leishmania phagocytosis IEA Reactome
Parasite infection TAS Reactome
Parasite infection IEA Reactome
Parasitic Infection Pathways TAS Reactome
Parasitic Infection Pathways IEA Reactome
RAC1 GTPase cycle TAS Reactome
RAC2 GTPase cycle TAS Reactome
RAC3 GTPase cycle TAS Reactome
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
Regulation of actin dynamics for phagocytic cup formation IEA Reactome
RHO GTPase cycle TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate WASPs and WAVEs TAS Reactome
RHO GTPases Activate WASPs and WAVEs IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by VEGF TAS Reactome
VEGFA-VEGFR2 Pathway TAS Reactome





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