Gene description for ANTXR2
Gene name anthrax toxin receptor 2
Gene symbol ANTXR2
Other names/aliases CMG-2
CMG2
HFS
ISH
JHF
Species Homo sapiens
 Database cross references - ANTXR2
ExoCarta ExoCarta_118429
Entrez Gene 118429
HGNC 21732
MIM 608041
UniProt P58335  
 ANTXR2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for ANTXR2
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    receptor activity GO:0004872 IEA
Biological Process
    toxin transport GO:1901998 IEA
    reproductive process GO:0022414 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    endosome membrane GO:0010008 TAS
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 IEA
    external side of plasma membrane GO:0009897 IEA
 Experiment description of studies that identified ANTXR2 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for ANTXR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ANTXR2 is involved
No pathways found





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