Gene description for CTNND2
Gene name catenin (cadherin-associated protein), delta 2
Gene symbol CTNND2
Other names/aliases GT24
Species Homo sapiens
 Database cross references - CTNND2
ExoCarta ExoCarta_1501
Entrez Gene 1501
HGNC 2516
MIM 604275
UniProt Q9UQB3  
 CTNND2 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
 Gene ontology annotations for CTNND2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    regulation of synaptic plasticity GO:0048167 IEA
    signal transduction GO:0007165 TAS
    single organismal cell-cell adhesion GO:0016337 IEA
    morphogenesis of a branching structure GO:0001763 IEA
    transcription, DNA-templated GO:0006351 IEA
    cell adhesion GO:0007155 TAS
    multicellular organismal development GO:0007275 IEA
    learning GO:0007612 IEA
Subcellular Localization
    perikaryon GO:0043204 IEA
    adherens junction GO:0005912 IEA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified CTNND2 in exosomes
Experiment ID 260
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CTNND2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSEN2  
Invivo Homo sapiens
2 PDZK3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 ERBB2IP 55914
Invivo Homo sapiens
Invitro Homo sapiens
4 LRRC7  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
5 PSEN1  
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CTNND2 is involved
No pathways found

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