Gene description for THSD7A
Gene name thrombospondin, type I, domain containing 7A
Gene symbol THSD7A
Other names/aliases -
Species Homo sapiens
 Database cross references - THSD7A
ExoCarta ExoCarta_221981
Vesiclepedia VP_221981
Entrez Gene 221981
HGNC 22207
MIM 612249
UniProt Q9UPZ6  
 THSD7A identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for THSD7A
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    angiogenesis GO:0001525 IEA
    actin cytoskeleton organization GO:0030036 IBA
    cell differentiation GO:0030154 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified THSD7A in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for THSD7A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SKIL  
Two-hybrid Homo sapiens
2 FHL3 2275
Affinity Capture-MS Homo sapiens
3 RPA3 6119
Proximity Label-MS Homo sapiens
4 KIF14 9928
Affinity Capture-MS Homo sapiens
5 RAD21 5885
Affinity Capture-MS Homo sapiens
6 DDX58 23586
Affinity Capture-RNA Homo sapiens
7 ASAP2 8853
Two-hybrid Homo sapiens
View the network image/svg+xml



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