Gene description for THSD7A
Gene name thrombospondin, type I, domain containing 7A
Gene symbol THSD7A
Other names/aliases -
Species Homo sapiens
 Database cross references - THSD7A
ExoCarta ExoCarta_221981
Vesiclepedia VP_221981
Entrez Gene 221981
HGNC 22207
MIM 612249
UniProt Q9UPZ6  
 THSD7A identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for THSD7A
Biological Process
    angiogenesis GO:0001525 IEA
    cell differentiation GO:0030154 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified THSD7A in exosomes
1
Experiment ID 224
MISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101|CD63|CD81
EV Enriched markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for THSD7A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which THSD7A is involved
PathwayEvidenceSource
O-glycosylation of TSR domain-containing proteins TAS Reactome





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