Gene description for Uggt1
Gene name UDP-glucose glycoprotein glucosyltransferase 1
Gene symbol Uggt1
Other names/aliases 0910001L17Rik
A930007H10Rik
AA589501
AI414429
AI448372
C820010P03Rik
GT
UGT1
Ugcgl1
Species Mus musculus
 Database cross references - Uggt1
ExoCarta ExoCarta_320011
Entrez Gene 320011
UniProt Q6P5E4  
 Uggt1 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
Pancreatic cells 19351151    
 Gene ontology annotations for Uggt1
Molecular Function
    acetylgalactosaminyltransferase activity GO:0008376 IEA
    lipopolysaccharide-1,5-galactosyltransferase activity GO:0035496 IEA
    unfolded protein binding GO:0051082 ISO
    dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity GO:0004583 IEA
    1-phenanthrol glycosyltransferase activity GO:0018716 IEA
    cellulose synthase activity GO:0016759 IEA
    O antigen polymerase activity GO:0008755 IEA
    beta-1,4-mannosyltransferase activity GO:0019187 IEA
    dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0042281 IEA
    mannosyltransferase activity GO:0000030 IEA
    alpha-1,2-mannosyltransferase activity GO:0000026 IEA
    oligosaccharyl transferase activity GO:0004576 IEA
    cytokinin 9-beta-glucosyltransferase activity GO:0080062 IEA
    glucosyltransferase activity GO:0046527 IEA
    dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0033556 IEA
    alpha-1,6-mannosyltransferase activity GO:0000009 IEA
    9-phenanthrol UDP-glucuronosyltransferase activity GO:0018715 IEA
    fucosyltransferase activity GO:0008417 IEA
    glycolipid mannosyltransferase activity GO:0004376 IEA
    lipopolysaccharide-1,6-galactosyltransferase activity GO:0008921 IEA
    dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0042283 IEA
    transferase activity GO:0016740 IEA
    alpha-1,3-galactosyltransferase activity GO:0001962 IEA
    alpha-(1->3)-fucosyltransferase activity GO:0046920 IEA
    alpha-1,3-mannosyltransferase activity GO:0000033 IEA
    alpha-1,2-galactosyltransferase activity GO:0031278 IEA
    inositol phosphoceramide synthase activity GO:0045140 IEA
    1,2-dihydroxy-phenanthrene glycosyltransferase activity GO:0018718 IEA
    alpha-(1->6)-fucosyltransferase activity GO:0046921 IEA
    protein binding GO:0005515 IPI
    acetylglucosaminyltransferase activity GO:0008375 IEA
    benzoic acid glucosyltransferase activity GO:0052641 IEA
    salicylic acid glucosyltransferase (glucoside-forming) activity GO:0052640 IEA
    phenanthrol glycosyltransferase activity GO:0019112 IEA
    9-phenanthrol glycosyltransferase activity GO:0018717 IEA
    UDP-glucose:glycoprotein glucosyltransferase activity GO:0003980 ISO
    transferase activity, transferring glycosyl groups GO:0016757 IEA
    indole-3-butyrate beta-glucosyltransferase activity GO:0052638 IEA
    galactosyltransferase activity GO:0008378 IEA
    dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity GO:0052824 IEA
    salicylic acid glucosyltransferase (ester-forming) activity GO:0052639 IEA
    chondroitin hydrolase activity GO:0052757 IEA
Biological Process
    UDP-glucosylation GO:0097359 ISO
    protein glycosylation GO:0006486 IEA
Subcellular Localization
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO
    endoplasmic reticulum GO:0005783 ISO
    extracellular exosome GO:0070062 ISO
    endoplasmic reticulum lumen GO:0005788 ISO
 Experiment description of studies that identified Uggt1 in exosomes
1
Experiment ID 264
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Uggt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Uggt1 is involved
PathwayEvidenceSource
ER Quality Control Compartment (ERQC) IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here