Gene description for Uggt1
Gene name UDP-glucose glycoprotein glucosyltransferase 1
Gene symbol Uggt1
Other names/aliases 0910001L17Rik
A930007H10Rik
AA589501
AI414429
AI448372
C820010P03Rik
GT
UGT1
Ugcgl1
Species Mus musculus
 Database cross references - Uggt1
ExoCarta ExoCarta_320011
Entrez Gene 320011
UniProt Q6P5E4  
 Uggt1 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
Pancreatic cells 19351151    
 Gene ontology annotations for Uggt1
Molecular Function
    acetylgalactosaminyltransferase activity GO:0008376 IEA
    lipopolysaccharide-1,5-galactosyltransferase activity GO:0035496 IEA
    unfolded protein binding GO:0051082 ISO
    dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity GO:0004583 IEA
    1-phenanthrol glycosyltransferase activity GO:0018716 IEA
    cellulose synthase activity GO:0016759 IEA
    O antigen polymerase activity GO:0008755 IEA
    beta-1,4-mannosyltransferase activity GO:0019187 IEA
    dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0042281 IEA
    mannosyltransferase activity GO:0000030 IEA
    alpha-1,2-mannosyltransferase activity GO:0000026 IEA
    oligosaccharyl transferase activity GO:0004576 IEA
    cytokinin 9-beta-glucosyltransferase activity GO:0080062 IEA
    glucosyltransferase activity GO:0046527 IEA
    dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0033556 IEA
    alpha-1,6-mannosyltransferase activity GO:0000009 IEA
    9-phenanthrol UDP-glucuronosyltransferase activity GO:0018715 IEA
    fucosyltransferase activity GO:0008417 IEA
    glycolipid mannosyltransferase activity GO:0004376 IEA
    lipopolysaccharide-1,6-galactosyltransferase activity GO:0008921 IEA
    dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0042283 IEA
    transferase activity GO:0016740 IEA
    alpha-1,3-galactosyltransferase activity GO:0001962 IEA
    alpha-(1->3)-fucosyltransferase activity GO:0046920 IEA
    alpha-1,3-mannosyltransferase activity GO:0000033 IEA
    alpha-1,2-galactosyltransferase activity GO:0031278 IEA
    inositol phosphoceramide synthase activity GO:0045140 IEA
    1,2-dihydroxy-phenanthrene glycosyltransferase activity GO:0018718 IEA
    alpha-(1->6)-fucosyltransferase activity GO:0046921 IEA
    protein binding GO:0005515 IPI
    acetylglucosaminyltransferase activity GO:0008375 IEA
    benzoic acid glucosyltransferase activity GO:0052641 IEA
    salicylic acid glucosyltransferase (glucoside-forming) activity GO:0052640 IEA
    phenanthrol glycosyltransferase activity GO:0019112 IEA
    9-phenanthrol glycosyltransferase activity GO:0018717 IEA
    UDP-glucose:glycoprotein glucosyltransferase activity GO:0003980 ISO
    transferase activity, transferring glycosyl groups GO:0016757 IEA
    indole-3-butyrate beta-glucosyltransferase activity GO:0052638 IEA
    galactosyltransferase activity GO:0008378 IEA
    dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity GO:0052824 IEA
    salicylic acid glucosyltransferase (ester-forming) activity GO:0052639 IEA
    chondroitin hydrolase activity GO:0052757 IEA
Biological Process
    UDP-glucosylation GO:0097359 ISO
    protein glycosylation GO:0006486 IEA
Subcellular Localization
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO
    endoplasmic reticulum GO:0005783 ISO
    extracellular exosome GO:0070062 ISO
    endoplasmic reticulum lumen GO:0005788 ISO
 Experiment description of studies that identified Uggt1 in exosomes
1
Experiment ID 264
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Uggt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Uggt1 is involved
PathwayEvidenceSource
ER Quality Control Compartment (ERQC) IEA Reactome





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