Gene description for Prosbeta4
Gene name Proteasome beta4 subunit
Gene symbol Prosbeta4
Other names/aliases 17331
Beta-4
CG17331
DmelCG17331
GC17331
PSMB2
Psmb2
beta4
Species Drosophila melanogaster
 Database cross references - Prosbeta4
ExoCarta ExoCarta_34999
Entrez Gene 34999
 Prosbeta4 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Prosbeta4
Molecular Function
    threonine-type endopeptidase activity GO:0004298 IEA
    endopeptidase activity GO:0004175 IC
Biological Process
    cellular response to DNA damage stimulus GO:0006974 IMP
    multicellular organism reproduction GO:0032504 IEP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP
Subcellular Localization
    proteasome core complex GO:0005839 IDA
    proteasome complex GO:0000502 IDA
 Experiment description of studies that identified Prosbeta4 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Prosbeta4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prosbeta4 is involved
No pathways found





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