Gene description for STAG3
Gene name stromal antigen 3
Gene symbol STAG3
Other names/aliases -
Species Homo sapiens
 Database cross references - STAG3
ExoCarta ExoCarta_10734
Vesiclepedia VP_10734
Entrez Gene 10734
HGNC 11356
MIM 608489
UniProt Q9UJ98  
 STAG3 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for STAG3
Molecular Function
    chromatin binding GO:0003682 IBA
Biological Process
    sister chromatid cohesion GO:0007062 IBA
    synaptonemal complex assembly GO:0007130 TAS
    establishment of meiotic sister chromatid cohesion GO:0034089 IBA
    establishment of meiotic sister chromatid cohesion GO:0034089 IMP
    establishment of meiotic sister chromatid cohesion GO:0034089 NAS
Subcellular Localization
    chromosome, centromeric region GO:0000775 IEA
    chromatin GO:0000785 IBA
    synaptonemal complex GO:0000795 TAS
    extracellular space GO:0005615 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    meiotic cohesin complex GO:0030893 IBA
    meiotic cohesin complex GO:0030893 IDA
    meiotic cohesin complex GO:0030893 NAS
 Experiment description of studies that identified STAG3 in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for STAG3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP4C 92421
Affinity Capture-MS Homo sapiens
2 PRC1 9055
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 PARP1 142
Negative Genetic Homo sapiens
5 SMC3 9126
Affinity Capture-Western Homo sapiens
6 SMC1A 8243
Affinity Capture-Western Homo sapiens
7 PARP2  
Negative Genetic Homo sapiens
8 KIF20A 10112
Affinity Capture-MS Homo sapiens
9 CHMP4B 128866
Affinity Capture-MS Homo sapiens
10 KIF23 9493
Affinity Capture-MS Homo sapiens
11 KIF14 9928
Affinity Capture-MS Homo sapiens
12 CIT 11113
Affinity Capture-MS Homo sapiens
13 ECT2 1894
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which STAG3 is involved
PathwayEvidenceSource
Cell Cycle IEA Reactome
Meiosis IEA Reactome
Meiotic synapsis IEA Reactome
Reproduction IEA Reactome





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