Gene description for FGD4
Gene name
FYVE, RhoGEF and PH domain containing 4
Gene symbol
FGD4
Other names/aliases
CMT4H FRABP ZFYVE6
Species
Homo sapiens
Database cross references - FGD4
ExoCarta
ExoCarta_121512
Vesiclepedia
VP_121512
Entrez Gene
121512
HGNC
19125
MIM
611104
UniProt
Q96M96
FGD4 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Gene ontology annotations for FGD4
Experiment description of studies that identified FGD4 in sEVs
1
Experiment ID
211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
"Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
2
Experiment ID
212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
"Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for FGD4
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
GSN
2934
Affinity Capture-MS
Homo sapiens
2
PLEC
5339
Affinity Capture-MS
Homo sapiens
3
C9orf16
Two-hybrid
Homo sapiens
4
CDC42
998
FRET
Homo sapiens
5
ACTB
60
Proximity Label-MS
Homo sapiens
6
NEFL
4747
Affinity Capture-MS
Homo sapiens
7
CCDC86
Affinity Capture-MS
Homo sapiens
8
FGD3
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
9
CUL3
8452
Affinity Capture-MS
Homo sapiens
10
CAPZA2
830
Affinity Capture-MS
Homo sapiens
11
DNAJC9
23234
Affinity Capture-MS
Homo sapiens
12
PDIA3
2923
Affinity Capture-MS
Homo sapiens
13
Myh9
17886
Affinity Capture-MS
Mus musculus
14
POTEE
445582
Affinity Capture-MS
Homo sapiens
15
PARK2
Affinity Capture-MS
Homo sapiens
16
KIF14
9928
Affinity Capture-MS
Homo sapiens
17
PRKCA
5578
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
18
CTDSPL2
Affinity Capture-MS
Homo sapiens
19
LANCL1
10314
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which FGD4 is involved