Gene description for Vars
Gene name valyl-tRNA synthetase
Gene symbol Vars
Other names/aliases Bat6
D17H6S56E
G7a
Vars2
Species Mus musculus
 Database cross references - Vars
ExoCarta ExoCarta_22321
Entrez Gene 22321
UniProt Q9Z1Q9  
 Vars identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Pancreatic cells 19351151    
 Gene ontology annotations for Vars
Molecular Function
    ATP binding GO:0005524 IEA
    ligase activity GO:0016874 IEA
    aminoacyl-tRNA editing activity GO:0002161 IEA
    aminoacyl-tRNA ligase activity GO:0004812 IEA
    valine-tRNA ligase activity GO:0004832 ISO
    nucleotide binding GO:0000166 IEA
Biological Process
    translation GO:0006412 IEA
    tRNA aminoacylation for protein translation GO:0006418 IEA
    valyl-tRNA aminoacylation GO:0006438 IBA
Subcellular Localization
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified Vars in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Vars
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Vars is involved
No pathways found





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