Gene description for Rab5
Gene name CG3664 gene product from transcript CG3664-RC
Gene symbol Rab5
Other names/aliases AAF51265
BAA88244
CG3664
DRab5
Dm Rab5
DmRab5
DmelCG3664
Drab5
RAB5
RAB5a
Rab
Rab-5
dRab5
l(2)k08232
rab5
Species Drosophila melanogaster
 Database cross references - Rab5
ExoCarta ExoCarta_33418
Entrez Gene 33418
 Rab5 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Rab5
Molecular Function
    GTP binding GO:0005525 NAS
    GTPase activity GO:0003924 NAS
    protein binding GO:0005515 IPI
Biological Process
    imaginal disc-derived leg joint morphogenesis GO:0016348 IGI
    establishment or maintenance of apical/basal cell polarity GO:0035088 IMP
    regulation of synapse structure or activity GO:0050803 IMP
    negative regulation of cell proliferation GO:0008285 IMP
    dendrite morphogenesis GO:0048813 IMP
    plasma membrane to endosome transport GO:0048227 IMP
    axonogenesis GO:0007409 IMP
    female meiosis chromosome segregation GO:0016321 IMP
    wing disc development GO:0035220 IMP
    imaginal disc-derived male genitalia morphogenesis GO:0048803 IMP
    epithelium development GO:0060429 IMP
    synaptic vesicle endocytosis GO:0048488 TAS
    endosomal vesicle fusion GO:0034058 IMP
    protein transport GO:0015031 IEA
    Notch receptor processing GO:0007220 IMP
    germarium-derived egg chamber formation GO:0007293 IMP
    dorsal closure, amnioserosa morphology change GO:0046664 IMP
    regulation of endocytosis GO:0030100 IMP
    cellularization GO:0007349 IMP
    synaptic vesicle to endosome fusion GO:0016189 TAS
    Rab protein signal transduction GO:0032482 ISS
    border follicle cell migration GO:0007298 IMP
    mitotic nuclear division GO:0007067 IMP
    endocytosis GO:0006897 IMP
    oogenesis GO:0048477 IMP
    vesicle-mediated transport GO:0016192 ISS
    chromatin organization GO:0006325 IMP
Subcellular Localization
    synapse GO:0045202 IDA
    early endosome GO:0005769 NAS
    plasma membrane GO:0005886 IDA
    vesicle GO:0031982 ISS
    lipid particle GO:0005811 IDA
    neuronal cell body GO:0043025 IDA
 Experiment description of studies that identified Rab5 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Rab5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab5 is involved
No pathways found





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