Gene description for ImpL3
Gene name Ecdysone-inducible gene L3
Gene symbol ImpL3
Other names/aliases CG10160
DmelCG10160
IMP-L3
IMPL3
Imp-L3
Impl3
LDH
Ld
Ldh
dLDH
dLdha
dmLDH
Species Drosophila melanogaster
 Database cross references - ImpL3
ExoCarta ExoCarta_45880
Entrez Gene 45880
UniProt Q95028  
 ImpL3 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for ImpL3
Molecular Function
    L-lactate dehydrogenase activity GO:0004459 NAS
Biological Process
    glycolytic process GO:0006096 NAS
    myoblast fusion GO:0007520 IMP
    carboxylic acid metabolic process GO:0019752 IEA
    somatic muscle development GO:0007525 IMP
    oxidation-reduction process GO:0055114 IEA
    carbohydrate metabolic process GO:0005975 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified ImpL3 in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ImpL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ImpL3 is involved
PathwayEvidenceSource
Pyruvate metabolism IEA Reactome





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