Gene description for SLC45A2
Gene name solute carrier family 45, member 2
Gene symbol SLC45A2
Other names/aliases 1A1
AIM1
MATP
OCA4
SHEP5
Species Homo sapiens
 Database cross references - SLC45A2
ExoCarta ExoCarta_51151
Vesiclepedia VP_51151
Entrez Gene 51151
HGNC 16472
MIM 606202
UniProt Q9UMX9  
 SLC45A2 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
 Gene ontology annotations for SLC45A2
Molecular Function
    D-glucose:proton symporter activity GO:0005356 ISS
    sucrose:proton symporter activity GO:0008506 IBA
    sucrose:proton symporter activity GO:0008506 ISS
Biological Process
    melanin biosynthetic process from tyrosine GO:0006583 IDA
    melanin biosynthetic process from tyrosine GO:0006583 ISS
    visual perception GO:0007601 IEA
    hexose transmembrane transport GO:0008645 IEA
    sucrose transport GO:0015770 ISS
    lysosomal lumen pH elevation GO:0035752 IDA
    lysosomal lumen pH elevation GO:0035752 ISS
    developmental pigmentation GO:0048066 ISS
Subcellular Localization
    membrane GO:0016020 IBA
    melanosome membrane GO:0033162 IDA
 Experiment description of studies that identified SLC45A2 in exosomes
1
Experiment ID 255
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 256
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC45A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF2E1 2960
Affinity Capture-MS Homo sapiens
2 SQRDL 58472
Affinity Capture-MS Homo sapiens
3 FAM63A 55793
Affinity Capture-MS Homo sapiens
4 MID1IP1  
Affinity Capture-MS Homo sapiens
5 UBB 7314
Affinity Capture-MS Homo sapiens
6 GAPDHS 26330
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TMEM63A 9725
Affinity Capture-MS Homo sapiens
8 PCNXL3 399909
Affinity Capture-MS Homo sapiens
9 EGFR 1956
Affinity Capture-MS Homo sapiens
10 CYHR1  
Affinity Capture-MS Homo sapiens
11 ATP2B2 491
Affinity Capture-MS Homo sapiens
12 ATG9A 79065
Affinity Capture-MS Homo sapiens
13 AMFR 267
Affinity Capture-MS Homo sapiens
14 SOX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC45A2 is involved
PathwayEvidenceSource
Melanin biosynthesis TAS Reactome
Metabolism TAS Reactome
Metabolism of amino acids and derivatives TAS Reactome





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