Gene description for DDX4
Gene name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Gene symbol	DDX4
Other names/aliases	VASA
Species	Homo sapiens
Database cross references - DDX4
ExoCarta	ExoCarta_54514
Vesiclepedia	VP_54514
Entrez Gene	54514
HGNC	18700
MIM	605281
UniProt	Q9NQI0
DDX4 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for DDX4

Molecular Function     DNA clamp loader activity GO:0003689 IEA     RNA helicase activity GO:0003724 IBA     mRNA binding GO:0003729 IBA     ATP binding GO:0005524 IEA     ATP hydrolysis activity GO:0016887 ISS     cohesin loader activity GO:0061775 IEA     chromatin extrusion motor activity GO:0140584 IEA     ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA     molecular condensate scaffold activity GO:0140693 EXP     ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA Biological Process     male meiotic nuclear division GO:0007140 ISS     male meiosis I GO:0007141 ISS     gamete generation GO:0007276 IBA     germ cell development GO:0007281 IBA     spermatogenesis GO:0007283 ISS     cell differentiation GO:0030154 IBA     flagellated sperm motility GO:0030317 IMP     piRNA processing GO:0034587 ISS     chromatin looping GO:0140588 IEA     transposable element silencing by piRNA-mediated heterochromatin formation GO:0141006 ISS     transposable element silencing by piRNA-mediated DNA methylation GO:0141196 ISS Subcellular Localization     nucleus GO:0005634 IBA     cytoplasm GO:0005737 IDA     P granule GO:0043186 IBA     perinuclear region of cytoplasm GO:0048471 IEA     pi-body GO:0071546 ISS     piP-body GO:0071547 ISS