Gene description for AP1AR
Gene name adaptor-related protein complex 1 associated regulatory protein
Gene symbol AP1AR
Other names/aliases 2C18
C4orf16
GBAR
PRO0971
gamma-BAR
Species Homo sapiens
 Database cross references - AP1AR
ExoCarta ExoCarta_55435
Vesiclepedia VP_55435
Entrez Gene 55435
HGNC 28808
MIM 610851
UniProt Q63HQ0  
 AP1AR identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for AP1AR
Molecular Function
    protein binding GO:0005515 IPI
    kinesin binding GO:0019894 IBA
    kinesin binding GO:0019894 IDA
    AP-1 adaptor complex binding GO:0035650 IBA
    AP-1 adaptor complex binding GO:0035650 IDA
Biological Process
    negative regulation of receptor recycling GO:0001920 IMP
    protein transport GO:0015031 IEA
    regulation of Arp2/3 complex-mediated actin nucleation GO:0034315 IEA
    substrate adhesion-dependent cell spreading GO:0034446 IEA
    vesicle targeting, trans-Golgi to endosome GO:0048203 IBA
    vesicle targeting, trans-Golgi to endosome GO:0048203 IDA
    negative regulation of substrate adhesion-dependent cell spreading GO:1900025 IMP
    negative regulation of cell motility GO:2000146 IEA
Subcellular Localization
    endosome GO:0005768 IBA
    early endosome GO:0005769 IEA
    late endosome GO:0005770 IEA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IEA
    transport vesicle GO:0030133 IDA
 Experiment description of studies that identified AP1AR in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AP1AR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STX7 8417
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 DUSP9  
Affinity Capture-MS Homo sapiens
3 RAB4A 5867
Proximity Label-MS Homo sapiens
4 STX6 10228
Proximity Label-MS Homo sapiens
5 RGS11  
Cross-Linking-MS (XL-MS) Homo sapiens
6 AP2B1 163
Proximity Label-MS Homo sapiens
7 ANKFY1 51479
Proximity Label-MS Homo sapiens
8 B3GAT1  
Proximity Label-MS Homo sapiens
9 CLTA 1211
Affinity Capture-MS Homo sapiens
10 ATG9A 79065
Proximity Label-MS Homo sapiens
11 CLTB 1212
Affinity Capture-MS Homo sapiens
12 LAMP2 3920
Proximity Label-MS Homo sapiens
13 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
14 KLC1 3831
Two-hybrid Homo sapiens
15 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
16 RAB9A 9367
Proximity Label-MS Homo sapiens
17 RAB5A 5868
Proximity Label-MS Homo sapiens
18 GOLGA1  
Proximity Label-MS Homo sapiens
19 DDX58 23586
Affinity Capture-RNA Homo sapiens
20 AP1S2 8905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 AP1S3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which AP1AR is involved
No pathways found





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