Gene description for ZNF556
Gene name zinc finger protein 556
Gene symbol ZNF556
Other names/aliases -
Species Homo sapiens
 Database cross references - ZNF556
ExoCarta ExoCarta_80032
Vesiclepedia VP_80032
Entrez Gene 80032
HGNC 25669
UniProt Q9HAH1  
 ZNF556 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ZNF556
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
 Experiment description of studies that identified ZNF556 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ZNF556
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRMT12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MRPS5 64969
Affinity Capture-MS Homo sapiens
3 MEOX2  
Two-hybrid Homo sapiens
4 ASAH1 427
Affinity Capture-MS Homo sapiens
5 NEDD8-MDP1 100528064
Affinity Capture-MS Homo sapiens
6 MRPS24 64951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 NEK7 140609
Affinity Capture-MS Homo sapiens
8 ZBTB3  
Two-hybrid Homo sapiens
9 TRIM39  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MTHFR 4524
Affinity Capture-MS Homo sapiens
11 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
12 LRP4 4038
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 UBE2O 63893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ANKS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF556 is involved
PathwayEvidenceSource
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
RNA Polymerase II Transcription TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here