Gene description for GPM6B
Gene name glycoprotein M6B
Gene symbol GPM6B
Other names/aliases M6B
Species Homo sapiens
 Database cross references - GPM6B
ExoCarta ExoCarta_2824
Vesiclepedia VP_2824
Entrez Gene 2824
HGNC 4461
MIM 300051
UniProt Q13491  
 GPM6B identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GPM6B
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of myelin sheath GO:0019911 IBA
Biological Process
    ossification GO:0001503 IEA
    nervous system development GO:0007399 NAS
    protein transport GO:0015031 IEA
    central nervous system myelination GO:0022010 IBA
    positive regulation of bone mineralization GO:0030501 IMP
    regulation of actin cytoskeleton organization GO:0032956 IMP
    negative regulation of serotonin uptake GO:0051612 IBA
    negative regulation of serotonin uptake GO:0051612 ISS
    regulation of focal adhesion assembly GO:0051893 IMP
    axon development GO:0061564 IBA
    extracellular matrix assembly GO:0085029 IMP
    negative regulation of protein localization to cell surface GO:2000009 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    myelin sheath GO:0043209 IBA
    membrane raft GO:0045121 IBA
    membrane raft GO:0045121 ISS
 Experiment description of studies that identified GPM6B in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GPM6B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARMC1 55156
Affinity Capture-MS Homo sapiens
2 CDCA8 55143
Affinity Capture-MS Homo sapiens
3 SEC63 11231
Affinity Capture-MS Homo sapiens
4 FAM162A 26355
Affinity Capture-MS Homo sapiens
5 DNAAF2  
Affinity Capture-MS Homo sapiens
6 NME2P1 283458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HAX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CLN8 2055
Two-hybrid Homo sapiens
9 ALG11  
Affinity Capture-MS Homo sapiens
10 EGFR 1956
PCA Homo sapiens
11 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
12 ESYT1 23344
Affinity Capture-MS Homo sapiens
13 TM9SF1 10548
Affinity Capture-MS Homo sapiens
14 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 DHRS7 51635
Affinity Capture-MS Homo sapiens
16 STOM 2040
Affinity Capture-MS Homo sapiens
17 DGUOK  
Affinity Capture-MS Homo sapiens
18 MTNR1B  
Two-hybrid Homo sapiens
19 NUFIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GPM6B is involved
No pathways found





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