Gene description for KRT26
Gene name keratin 26, type I
Gene symbol KRT26
Other names/aliases CK26
K25IRS2
K26
KRT25B
Species Homo sapiens
 Database cross references - KRT26
ExoCarta ExoCarta_353288
Vesiclepedia VP_353288
Entrez Gene 353288
HGNC 30840
UniProt Q7Z3Y9  
 KRT26 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for KRT26
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
Biological Process
    epithelial cell differentiation GO:0030855 IBA
    intermediate filament organization GO:0045109 IBA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    intermediate filament GO:0005882 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified KRT26 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for KRT26
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC19A1 6573
Two-hybrid Homo sapiens
2 KRT85  
Two-hybrid Homo sapiens
3 KRT3 3850
Two-hybrid Homo sapiens
4 KRT1 3848
Two-hybrid Homo sapiens
5 BLOC1S2 282991
Two-hybrid Homo sapiens
6 KIFC3 3801
Two-hybrid Homo sapiens
7 KRT6A 3853
Two-hybrid Homo sapiens
8 CCDC146  
Two-hybrid Homo sapiens
9 TXLNB  
Two-hybrid Homo sapiens
10 SNAPIN 23557
Two-hybrid Homo sapiens
11 KRT81  
Two-hybrid Homo sapiens
12 KRT6C 286887
Two-hybrid Homo sapiens
13 KRT71 112802
Two-hybrid Homo sapiens
14 KRT74 121391
Two-hybrid Homo sapiens
15 KRT75 9119
Two-hybrid Homo sapiens
16 MCCD1  
Two-hybrid Homo sapiens
17 TRIB3  
Two-hybrid Homo sapiens
18 HGS 9146
Two-hybrid Homo sapiens
19 USHBP1  
Two-hybrid Homo sapiens
20 WASH1 100287171
Two-hybrid Homo sapiens
21 FAM86C1  
Two-hybrid Homo sapiens
22 UCHL5 51377
Reconstituted Complex Homo sapiens
23 SUOX  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which KRT26 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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