Gene description for PARP10
Gene name poly (ADP-ribose) polymerase family, member 10
Gene symbol PARP10
Other names/aliases ARTD10
Species Homo sapiens
 Database cross references - PARP10
ExoCarta ExoCarta_84875
Entrez Gene 84875
HGNC 25895
MIM 609564
UniProt Q53GL7  
 PARP10 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Thymus 23844026    
 Gene ontology annotations for PARP10
Molecular Function
    K63-linked polyubiquitin binding GO:0070530 IMP
    protein binding GO:0005515 IPI
    NAD+ ADP-ribosyltransferase activity GO:0003950 IMP
Biological Process
    negative regulation of gene expression GO:0010629 IMP
    negative regulation of fibroblast proliferation GO:0048147 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP
    negative regulation of protein K63-linked ubiquitination GO:1900045 IMP
    protein ADP-ribosylation GO:0006471 IMP
    protein poly-ADP-ribosylation GO:0070212 IDA
    protein auto-ADP-ribosylation GO:0070213 IMP
    negative regulation of protein import into nucleus, translocation GO:0033159 IMP
    negative regulation of viral genome replication GO:0045071 IMP
    regulation of chromatin assembly GO:0010847 IDA
Subcellular Localization
    nucleolus GO:0005730 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    Golgi apparatus GO:0005794 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified PARP10 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PARP10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PARP10 is involved
No pathways found





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