Gene description for GDAP1
Gene name ganglioside induced differentiation associated protein 1
Gene symbol GDAP1
Other names/aliases CMT4
CMT4A
CMTRIA
Species Homo sapiens
 Database cross references - GDAP1
ExoCarta ExoCarta_54332
Vesiclepedia VP_54332
Entrez Gene 54332
HGNC 15968
MIM 606598
UniProt Q8TB36  
 GDAP1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for GDAP1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    mitochondrial fission GO:0000266 IBA
    mitochondrial fission GO:0000266 IDA
    protein targeting to mitochondrion GO:0006626 IBA
    protein targeting to mitochondrion GO:0006626 IMP
    mitochondrial fusion GO:0008053 IBA
    mitochondrial fusion GO:0008053 IMP
    response to retinoic acid GO:0032526 IEA
    cellular response to vitamin D GO:0071305 IEA
Subcellular Localization
    nucleus GO:0005634 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IBA
    mitochondrial outer membrane GO:0005741 IDA
    peroxisomal membrane GO:0005778 TAS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified GDAP1 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for GDAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABHD16A 7920
Two-hybrid Homo sapiens
2 HBB 3043
Co-fractionation Homo sapiens
3 CLCN7 1186
Two-hybrid Homo sapiens
4 TUBB 203068
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 PSAP 5660
Co-fractionation Homo sapiens
6 FAF2 23197
Co-fractionation Homo sapiens
7 TMEM218  
Two-hybrid Homo sapiens
8 Tmed10 68581
Affinity Capture-MS Mus musculus
9 TNFSF8  
Affinity Capture-MS Homo sapiens
10 TMEM14B  
Two-hybrid Homo sapiens
11 PNLIPRP1  
Two-hybrid Homo sapiens
12 EYA2  
Affinity Capture-MS Homo sapiens
13 CPQ 10404
Affinity Capture-MS Homo sapiens
14 SHMT2 6472
Affinity Capture-RNA Homo sapiens
15 OS9 10956
Affinity Capture-MS Homo sapiens
16 SUZ12  
Affinity Capture-MS Homo sapiens
17 APOD 347
Two-hybrid Homo sapiens
18 NXF1 10482
Affinity Capture-RNA Homo sapiens
19 FIS1 51024
Affinity Capture-Western Homo sapiens
20 MINPP1 9562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RAMP2  
Affinity Capture-MS Homo sapiens
22 NTRK1 4914
Affinity Capture-MS Homo sapiens
23 FAM174A 345757
Affinity Capture-MS Homo sapiens
24 FAM114A1 92689
Two-hybrid Homo sapiens
25 STARD4  
Two-hybrid Homo sapiens
26 Prkaa1  
Affinity Capture-MS Mus musculus
27 SMPD1 6609
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GDAP1 is involved
PathwayEvidenceSource
Class I peroxisomal membrane protein import TAS Reactome
Protein localization TAS Reactome





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