Gene description for Snd1
Gene name staphylococcal nuclease and tudor domain containing 1
Gene symbol Snd1
Other names/aliases AL033314
Tudor-SN
Species Mus musculus
 Database cross references - Snd1
ExoCarta ExoCarta_56463
Vesiclepedia VP_56463
Entrez Gene 56463
UniProt Q78PY7  
 Snd1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Neural stem cells 25242146    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snd1
Molecular Function
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 IEA
    RNA binding GO:0003723 ISO
    nuclease activity GO:0004518 IBA
    endonuclease activity GO:0004519 ISO
    RNA endonuclease activity GO:0004521 IEA
    RNA endonuclease activity GO:0004521 ISO
    protein binding GO:0005515 IPI
    endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters GO:0016894 IEA
    RISC complex binding GO:1905172 IEA
    RISC complex binding GO:1905172 ISO
Biological Process
    mRNA catabolic process GO:0006402 IBA
    regulation of cell cycle process GO:0010564 IEA
    regulation of cell cycle process GO:0010564 ISO
    miRNA catabolic process GO:0010587 IEA
    miRNA catabolic process GO:0010587 ISO
    regulatory ncRNA-mediated gene silencing GO:0031047 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    RNAi effector complex GO:0031332 IEA
    melanosome GO:0042470 IEA
    dense body GO:0097433 IDA
 Experiment description of studies that identified Snd1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 263
MISEV standards
Biophysical techniques
CD63|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rpl28 19943
Co-fractionation Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
3 Elf5  
Affinity Capture-MS Mus musculus
4 Raver1  
Co-fractionation Mus musculus
5 Pou5f1  
Affinity Capture-MS Mus musculus
6 Rps2 16898
Co-fractionation Mus musculus
7 Rps23 66475
Co-fractionation Mus musculus
8 Kctd13  
Affinity Capture-MS Mus musculus
9 Atg16l1  
Affinity Capture-MS Mus musculus
10 Rps6 20104
Co-fractionation Mus musculus
11 Rpl4 67891
Co-fractionation Mus musculus
12 Tmem173  
Proximity Label-MS Mus musculus
13 Rps11 27207
Co-fractionation Mus musculus
14 Rps9 76846
Co-fractionation Mus musculus
15 Ddx3x 13205
Co-fractionation Mus musculus
16 Rps3a1 20091
Co-fractionation Mus musculus
17 Rpl23 65019
Co-fractionation Mus musculus
18 Rpl23a 268449
Co-fractionation Mus musculus
19 Rpl35 66489
Co-fractionation Mus musculus
20 Rpl3 27367
Co-fractionation Mus musculus
21 Tia1  
Co-fractionation Mus musculus
22 Rps16 20055
Co-fractionation Mus musculus
23 Fancd2  
Affinity Capture-MS Mus musculus
24 Rpl8 26961
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Snd1 is involved
No pathways found





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