Gene description for HIST1H4G
Gene name histone cluster 1, H4g
Gene symbol HIST1H4G
Other names/aliases H4/l
H4FL
Species Homo sapiens
 Database cross references - HIST1H4G
ExoCarta ExoCarta_8369
Vesiclepedia VP_8369
Entrez Gene 8369
HGNC 4792
MIM 602832
UniProt Q99525  
 HIST1H4G identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for HIST1H4G
Molecular Function
    DNA binding GO:0003677 IBA
    protein binding GO:0005515 IPI
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    nucleosome assembly GO:0006334 IBA
Subcellular Localization
    nucleosome GO:0000786 IEA
    nucleus GO:0005634 HDA
 Experiment description of studies that identified HIST1H4G in exosomes
1
Experiment ID 76
MISEV standards
EM
Biophysical techniques
TSG101|GAPDH|HSP90|CD81|CD9|CD63|LAMP1|MHCI
Enriched markers
HSP90B1
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for HIST1H4G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 H2AFZ 3015
Affinity Capture-Western Homo sapiens
2 TMED8 283578
Two-hybrid Homo sapiens
3 AGTRAP 57085
Two-hybrid Homo sapiens
4 APOC1  
Two-hybrid Homo sapiens
5 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
6 VRK1 7443
Affinity Capture-MS Homo sapiens
7 C2orf47  
Two-hybrid Homo sapiens
8 MYCN  
Affinity Capture-MS Homo sapiens
9 CIDEB  
Two-hybrid Homo sapiens
10 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
11 KIF20A 10112
Affinity Capture-MS Homo sapiens
12 CHMP4B 128866
Affinity Capture-MS Homo sapiens
13 PRC1 9055
Affinity Capture-MS Homo sapiens
14 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
15 HMGN1  
Affinity Capture-MS Homo sapiens
16 KIF23 9493
Affinity Capture-MS Homo sapiens
17 FGF14  
Two-hybrid Homo sapiens
18 ANLN 54443
Affinity Capture-MS Homo sapiens
19 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
20 HIST2H2BE 8349
Cross-Linking-MS (XL-MS) Homo sapiens
21 ECT2 1894
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HIST1H4G is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here