Gene description for HIST1H4G
Gene name histone cluster 1, H4g
Gene symbol HIST1H4G
Other names/aliases H4/l
H4FL
Species Homo sapiens
 Database cross references - HIST1H4G
ExoCarta ExoCarta_8369
Entrez Gene 8369
HGNC 4792
MIM 602832
UniProt Q99525  
 HIST1H4G identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for HIST1H4G
Molecular Function
    DNA binding GO:0003677 IEA
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    biological_process GO:0008150 ND
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleosome GO:0000786 IEA
 Experiment description of studies that identified HIST1H4G in exosomes
1
Experiment ID 76
ISEV standards
EM
EV Biophysical techniques
TSG101|GAPDH|HSP90
EV Cytosolic markers
CD81|CD9|CD63|LAMP1|MHCI
EV Membrane markers
HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A.
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for HIST1H4G
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HIST1H4G is involved
No pathways found





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