Gene description for ALKBH5
Gene name AlkB family member 5, RNA demethylase
Gene symbol ALKBH5
Other names/aliases ABH5
OFOXD
OFOXD1
Species Homo sapiens
 Database cross references - ALKBH5
ExoCarta ExoCarta_54890
Entrez Gene 54890
HGNC 25996
MIM 613303
UniProt Q6P6C2  
 ALKBH5 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ALKBH5
Molecular Function
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0016706 IDA
    oxidative RNA demethylase activity GO:0035515 IDA
    metal ion binding GO:0046872 IEA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    oxidative single-stranded RNA demethylation GO:0035553 IDA
    response to hypoxia GO:0001666 IDA
    mRNA export from nucleus GO:0006406 IMP
    positive regulation of defense response to virus by host GO:0002230 IMP
    cell differentiation GO:0030154 IEA
    mRNA processing GO:0006397 IMP
    spermatogenesis GO:0007283 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified ALKBH5 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ALKBH5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ALKBH5 is involved
No pathways found





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